Cathepsin G Is Expressed by Acute Lymphoblastic Leukemia and Is a Potential Immunotherapeutic Target

Cathepsin G (CG) is a myeloid azurophil granule protease that is highly expressed by acute myeloid leukemia (AML) blasts and leukemia stem cells. We previously identified CG1 (FLLPTGAEA), a human leukocyte antigen-A2-restricted nonameric peptide derived from CG, as an immunogenic target in AML. In t...

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Detalles Bibliográficos
Autores principales: Khan, Maliha, Carmona, Selena, Sukhumalchandra, Pariya, Roszik, Jason, Philips, Anne, Perakis, Alexander A., Kerros, Celine, Zhang, Mao, Qiao, Na, John, Lisa S. St., Zope, Madhushree, Goldberg, Jonathan, Qazilbash, Mariam, Jakher, Haroon, Clise-Dwyer, Karen, Qiu, Yihua, Mittendorf, Elizabeth A., Molldrem, Jeffrey J., Kornblau, Steven M., Alatrash, Gheath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790053/
https://www.ncbi.nlm.nih.gov/pubmed/29422892
http://dx.doi.org/10.3389/fimmu.2017.01975

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