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Irisin, physical activity and fitness status in healthy humans: No association under resting conditions in a cross-sectional study
Regular physical activity and physical fitness are closely related to a positive health status in humans. In this context, the muscle becomes more important due to its function as an endocrine organ. Muscle tissue secretes “myokines” in response to physical activity and it is speculated that these m...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790221/ https://www.ncbi.nlm.nih.gov/pubmed/29381744 http://dx.doi.org/10.1371/journal.pone.0189254 |
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author | Biniaminov, Nathalie Bandt, Susanne Roth, Alexander Haertel, Sascha Neumann, Rainer Bub, Achim |
author_facet | Biniaminov, Nathalie Bandt, Susanne Roth, Alexander Haertel, Sascha Neumann, Rainer Bub, Achim |
author_sort | Biniaminov, Nathalie |
collection | PubMed |
description | Regular physical activity and physical fitness are closely related to a positive health status in humans. In this context, the muscle becomes more important due to its function as an endocrine organ. Muscle tissue secretes “myokines” in response to physical activity and it is speculated that these myokines are involved in physical activity induced positive health effects. Recently, the newly discovered myokine Irisin thought to be secreted by the muscle in response to physical activity and might be related to the health inducing effect by inducing browning of white adipose tissue. Speculating that myokines at least partly mediate exercise related health effects one would assume that regular physical activity and physical fitness are associated with resting Irisin concentrations in healthy humans. To investigate the association between resting Irisin concentration and either short-term physical activity, habitual physical activity, or physical fitness, data of 300 healthy participants from the cross-sectional KarMeN-study were analyzed. By applying different activity measurements we determined short-term and habitual physical activity, as well as physical fitness. Fasting serum samples were collected to determine resting Irisin concentrations by Enzyme-linked Immunosorbent Assay. Multivariate linear regression analysis served to investigate associations of the individual physical activity parameters with Irisin concentrations. Therefore, lean body mass and total fat mass (both determined by dual-energy X-ray absorptiometry) as well as age and parameters of glucose metabolism were included as confounders in multivariate linear regression analysis. Results showed that Irisin serum concentrations were not related to measures of physical activity and physical fitness in healthy humans under resting conditions, irrespective of the applied methods. Therefore we assume that if physical activity related effects are partly induced by myokines, permanently increased Irisin serum concentration may not be necessary to induce health-related exercise effects. |
format | Online Article Text |
id | pubmed-5790221 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-57902212018-02-13 Irisin, physical activity and fitness status in healthy humans: No association under resting conditions in a cross-sectional study Biniaminov, Nathalie Bandt, Susanne Roth, Alexander Haertel, Sascha Neumann, Rainer Bub, Achim PLoS One Research Article Regular physical activity and physical fitness are closely related to a positive health status in humans. In this context, the muscle becomes more important due to its function as an endocrine organ. Muscle tissue secretes “myokines” in response to physical activity and it is speculated that these myokines are involved in physical activity induced positive health effects. Recently, the newly discovered myokine Irisin thought to be secreted by the muscle in response to physical activity and might be related to the health inducing effect by inducing browning of white adipose tissue. Speculating that myokines at least partly mediate exercise related health effects one would assume that regular physical activity and physical fitness are associated with resting Irisin concentrations in healthy humans. To investigate the association between resting Irisin concentration and either short-term physical activity, habitual physical activity, or physical fitness, data of 300 healthy participants from the cross-sectional KarMeN-study were analyzed. By applying different activity measurements we determined short-term and habitual physical activity, as well as physical fitness. Fasting serum samples were collected to determine resting Irisin concentrations by Enzyme-linked Immunosorbent Assay. Multivariate linear regression analysis served to investigate associations of the individual physical activity parameters with Irisin concentrations. Therefore, lean body mass and total fat mass (both determined by dual-energy X-ray absorptiometry) as well as age and parameters of glucose metabolism were included as confounders in multivariate linear regression analysis. Results showed that Irisin serum concentrations were not related to measures of physical activity and physical fitness in healthy humans under resting conditions, irrespective of the applied methods. Therefore we assume that if physical activity related effects are partly induced by myokines, permanently increased Irisin serum concentration may not be necessary to induce health-related exercise effects. Public Library of Science 2018-01-30 /pmc/articles/PMC5790221/ /pubmed/29381744 http://dx.doi.org/10.1371/journal.pone.0189254 Text en © 2018 Biniaminov et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Biniaminov, Nathalie Bandt, Susanne Roth, Alexander Haertel, Sascha Neumann, Rainer Bub, Achim Irisin, physical activity and fitness status in healthy humans: No association under resting conditions in a cross-sectional study |
title | Irisin, physical activity and fitness status in healthy humans: No association under resting conditions in a cross-sectional study |
title_full | Irisin, physical activity and fitness status in healthy humans: No association under resting conditions in a cross-sectional study |
title_fullStr | Irisin, physical activity and fitness status in healthy humans: No association under resting conditions in a cross-sectional study |
title_full_unstemmed | Irisin, physical activity and fitness status in healthy humans: No association under resting conditions in a cross-sectional study |
title_short | Irisin, physical activity and fitness status in healthy humans: No association under resting conditions in a cross-sectional study |
title_sort | irisin, physical activity and fitness status in healthy humans: no association under resting conditions in a cross-sectional study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790221/ https://www.ncbi.nlm.nih.gov/pubmed/29381744 http://dx.doi.org/10.1371/journal.pone.0189254 |
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