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The Rationale for Growth Hormone Therapy in Children with Short Stature
Growth hormone (GH) was first isolated from cadaver pituitary glands, requiring laborious and expensive collection of glands, followed by extraction and purification of the hormone. This limited supply restricted its use to children with severe GH deficiency who were treated with low dosages and sub...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Galenos Publishing
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790327/ https://www.ncbi.nlm.nih.gov/pubmed/29280742 http://dx.doi.org/10.4274/jcrpe.2017.S003 |
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author | Deodati, Annalisa Cianfarani, Stefano |
author_facet | Deodati, Annalisa Cianfarani, Stefano |
author_sort | Deodati, Annalisa |
collection | PubMed |
description | Growth hormone (GH) was first isolated from cadaver pituitary glands, requiring laborious and expensive collection of glands, followed by extraction and purification of the hormone. This limited supply restricted its use to children with severe GH deficiency who were treated with low dosages and suboptimal schedules. The development of recombinant DNA-derived GH, allowed the production of virtually unlimited amounts of GH, leading to the approval for therapy for a large number of childhood conditions characterized by non-GH deficient short stature. The aim of this review is to provide a critical overview on the daily use of GH in two paradigmatic conditions of non-GH deficient short stature which are children born small for gestational age and with idiopathic short stature, highlighting the available strength of evidence for efficacy and safety. |
format | Online Article Text |
id | pubmed-5790327 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Galenos Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-57903272018-02-02 The Rationale for Growth Hormone Therapy in Children with Short Stature Deodati, Annalisa Cianfarani, Stefano J Clin Res Pediatr Endocrinol Review Growth hormone (GH) was first isolated from cadaver pituitary glands, requiring laborious and expensive collection of glands, followed by extraction and purification of the hormone. This limited supply restricted its use to children with severe GH deficiency who were treated with low dosages and suboptimal schedules. The development of recombinant DNA-derived GH, allowed the production of virtually unlimited amounts of GH, leading to the approval for therapy for a large number of childhood conditions characterized by non-GH deficient short stature. The aim of this review is to provide a critical overview on the daily use of GH in two paradigmatic conditions of non-GH deficient short stature which are children born small for gestational age and with idiopathic short stature, highlighting the available strength of evidence for efficacy and safety. Galenos Publishing 2017-12 2017-12-30 /pmc/articles/PMC5790327/ /pubmed/29280742 http://dx.doi.org/10.4274/jcrpe.2017.S003 Text en ©Copyright 2017 by Turkish Pediatric Endocrinology and Diabetes Society The Journal of Clinical Research in Pediatric Endocrinology published by Galenos Publishing House. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Deodati, Annalisa Cianfarani, Stefano The Rationale for Growth Hormone Therapy in Children with Short Stature |
title | The Rationale for Growth Hormone Therapy in Children with Short Stature |
title_full | The Rationale for Growth Hormone Therapy in Children with Short Stature |
title_fullStr | The Rationale for Growth Hormone Therapy in Children with Short Stature |
title_full_unstemmed | The Rationale for Growth Hormone Therapy in Children with Short Stature |
title_short | The Rationale for Growth Hormone Therapy in Children with Short Stature |
title_sort | rationale for growth hormone therapy in children with short stature |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790327/ https://www.ncbi.nlm.nih.gov/pubmed/29280742 http://dx.doi.org/10.4274/jcrpe.2017.S003 |
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