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The Rationale for Growth Hormone Therapy in Children with Short Stature

Growth hormone (GH) was first isolated from cadaver pituitary glands, requiring laborious and expensive collection of glands, followed by extraction and purification of the hormone. This limited supply restricted its use to children with severe GH deficiency who were treated with low dosages and sub...

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Detalles Bibliográficos
Autores principales: Deodati, Annalisa, Cianfarani, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790327/
https://www.ncbi.nlm.nih.gov/pubmed/29280742
http://dx.doi.org/10.4274/jcrpe.2017.S003
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author Deodati, Annalisa
Cianfarani, Stefano
author_facet Deodati, Annalisa
Cianfarani, Stefano
author_sort Deodati, Annalisa
collection PubMed
description Growth hormone (GH) was first isolated from cadaver pituitary glands, requiring laborious and expensive collection of glands, followed by extraction and purification of the hormone. This limited supply restricted its use to children with severe GH deficiency who were treated with low dosages and suboptimal schedules. The development of recombinant DNA-derived GH, allowed the production of virtually unlimited amounts of GH, leading to the approval for therapy for a large number of childhood conditions characterized by non-GH deficient short stature. The aim of this review is to provide a critical overview on the daily use of GH in two paradigmatic conditions of non-GH deficient short stature which are children born small for gestational age and with idiopathic short stature, highlighting the available strength of evidence for efficacy and safety.
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spelling pubmed-57903272018-02-02 The Rationale for Growth Hormone Therapy in Children with Short Stature Deodati, Annalisa Cianfarani, Stefano J Clin Res Pediatr Endocrinol Review Growth hormone (GH) was first isolated from cadaver pituitary glands, requiring laborious and expensive collection of glands, followed by extraction and purification of the hormone. This limited supply restricted its use to children with severe GH deficiency who were treated with low dosages and suboptimal schedules. The development of recombinant DNA-derived GH, allowed the production of virtually unlimited amounts of GH, leading to the approval for therapy for a large number of childhood conditions characterized by non-GH deficient short stature. The aim of this review is to provide a critical overview on the daily use of GH in two paradigmatic conditions of non-GH deficient short stature which are children born small for gestational age and with idiopathic short stature, highlighting the available strength of evidence for efficacy and safety. Galenos Publishing 2017-12 2017-12-30 /pmc/articles/PMC5790327/ /pubmed/29280742 http://dx.doi.org/10.4274/jcrpe.2017.S003 Text en ©Copyright 2017 by Turkish Pediatric Endocrinology and Diabetes Society The Journal of Clinical Research in Pediatric Endocrinology published by Galenos Publishing House. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Deodati, Annalisa
Cianfarani, Stefano
The Rationale for Growth Hormone Therapy in Children with Short Stature
title The Rationale for Growth Hormone Therapy in Children with Short Stature
title_full The Rationale for Growth Hormone Therapy in Children with Short Stature
title_fullStr The Rationale for Growth Hormone Therapy in Children with Short Stature
title_full_unstemmed The Rationale for Growth Hormone Therapy in Children with Short Stature
title_short The Rationale for Growth Hormone Therapy in Children with Short Stature
title_sort rationale for growth hormone therapy in children with short stature
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790327/
https://www.ncbi.nlm.nih.gov/pubmed/29280742
http://dx.doi.org/10.4274/jcrpe.2017.S003
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