Inhibition of oxidative stress in cholinergic projection neurons fully rescues aging-associated olfactory circuit degeneration in Drosophila

Loss of the sense of smell is among the first signs of natural aging and neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Cellular and molecular mechanisms promoting this smell loss are not understood. Here, we show that Drosophila melanogaster also loses olfaction before vision with...

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Detalles Bibliográficos
Autores principales: Hussain, Ashiq, Pooryasin, Atefeh, Zhang, Mo, Loschek, Laura F, La Fortezza, Marco, Friedrich, Anja B, Blais, Catherine-Marie, Üçpunar, Habibe K, Yépez, Vicente A, Lehmann, Martin, Gompel, Nicolas, Gagneur, Julien, Sigrist, Stephan J, Grunwald Kadow, Ilona C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790380/
https://www.ncbi.nlm.nih.gov/pubmed/29345616
http://dx.doi.org/10.7554/eLife.32018

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