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Suppression of FGFR3- and MYC-dependent oncogenesis by tubacin: association with HDAC6-dependent and independent activities

Fibroblast growth factor receptor 3 (FGFR3) is amplified, translocated or mutated in a number of different human cancer types, but most commonly in bladder cancers. We previously found that the accumulation of FGFR3 is dependent on histone deacetylase 6 (HDAC6). Here we show that HDAC6 loss or inhib...

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Detalles Bibliográficos
Autores principales: Ota, Sara, Zhou, Zi-Qiang, Hurlin, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790455/
https://www.ncbi.nlm.nih.gov/pubmed/29423038
http://dx.doi.org/10.18632/oncotarget.22816