Enhanced anti-tumor efficacy and mechanisms associated with docetaxel-piperine combination- in vitro and in vivo investigation using a taxane-resistant prostate cancer model

Docetaxel (DTX) is widely used for metastatic castrated resistant prostate cancer, but its efficacy is often compromised by drug resistance associated with low intracellular concentrations. Piperine (PIP) could enhance the bioavailability of other drugs via the inhibition of CYPs and P-gp activities...

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Detalles Bibliográficos
Autores principales: Li, Chenrui, Wang, Zhijun, Wang, Qian, Ka Yan Ho, Rebecca Lucinda, Huang, Ying, Chow, Moses S.S., Kei Lam, Christopher Wai, Zuo, Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790467/
https://www.ncbi.nlm.nih.gov/pubmed/29423050
http://dx.doi.org/10.18632/oncotarget.23235

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