Reduced recruitment of 53BP1 during interstrand crosslink repair is associated with genetically inherited attenuation of mitomycin C sensitivity in a family with Fanconi anemia

The Fanconi anemia (FA) pathway is implicated in the repair of DNA interstrand crosslinks (ICL). In this process, it has been shown that FA factors regulate the choice for DNA double strand break repair towards homologous recombination (HR). As this mechanism is impaired in FA deficient cells expose...

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Detalles Bibliográficos
Autores principales: Lesport, Emilie, Ferster, Alina, Biver, Armand, Roch, Benoit, Vasquez, Nadia, Jabado, Nada, Vives, Francina Langa, Revy, Patrick, Soulier, Jean, de Villartay, Jean-Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790499/
https://www.ncbi.nlm.nih.gov/pubmed/29423082
http://dx.doi.org/10.18632/oncotarget.23375

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