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Lung cancer: changes in histology, gender, and age over the last 30 years in Brazil
OBJECTIVE: To describe the trends in tumor histology, gender and age among patients with non-small cell lung cancer (NSCLC) treated with lung resection. The histology of lung cancer has changed in developed countries, and there is still little information available on the topic for developing countr...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Sociedade Brasileira de Pneumologia e Tisiologia
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790654/ https://www.ncbi.nlm.nih.gov/pubmed/29160382 http://dx.doi.org/10.1590/S1806-37562016000000339 |
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author | Tsukazan, Maria Teresa Ruiz Vigo, Álvaro da Silva, Vinícius Duval Barrios, Carlos Henrique Rios, Jayme de Oliveira Pinto, José Antônio de Figueiredo |
author_facet | Tsukazan, Maria Teresa Ruiz Vigo, Álvaro da Silva, Vinícius Duval Barrios, Carlos Henrique Rios, Jayme de Oliveira Pinto, José Antônio de Figueiredo |
author_sort | Tsukazan, Maria Teresa Ruiz |
collection | PubMed |
description | OBJECTIVE: To describe the trends in tumor histology, gender and age among patients with non-small cell lung cancer (NSCLC) treated with lung resection. The histology of lung cancer has changed in developed countries, and there is still little information available on the topic for developing countries. METHODS: This was a retrospective study of 1,030 patients with NSCLC treated with lung resection between 1986 and 2015 at a university hospital in southern Brazil. Differences in histology, stage, and type of surgery were analyzed by gender and for three periods (1986-1995, 1996-2005, and 2006-2015). RESULTS: Most (64.5%) of the patients were males, and the main histological types were squamous cell carcinoma (in 40.6%) and adenocarcinoma (in 44.5%). The mean age at surgery during the first period was 56.4 years for women and 58.9 years for men, compared with 62.2 for women and 64.6 for men in the third period (p < 0.001). The proportion of females increased from 26.6% in the first period to 44.1% in the third. From the first to the third period, the proportion of patients with squamous cell carcinoma decreased from 49.6% to 34.8% overall (p < 0.001), decreasing to an even greater degree (from 38.9% to 23.2%) among men. Among the NSCLC patients in our sample, females with adenocarcinoma accounted for 11.9% in the first period and 24.0% in the third period (p < 0.001). CONCLUSIONS: As has been seen in developed countries, the rates of lung cancer in females in southern Brazil have been rising over the last three decades, although they have yet to surpass those observed for males in the region. The incidence of squamous cell carcinoma has decreased in males, approaching adenocarcinoma rates, whereas adenocarcinoma has significantly increased among women. |
format | Online Article Text |
id | pubmed-5790654 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Sociedade Brasileira de Pneumologia e Tisiologia |
record_format | MEDLINE/PubMed |
spelling | pubmed-57906542018-02-08 Lung cancer: changes in histology, gender, and age over the last 30 years in Brazil Tsukazan, Maria Teresa Ruiz Vigo, Álvaro da Silva, Vinícius Duval Barrios, Carlos Henrique Rios, Jayme de Oliveira Pinto, José Antônio de Figueiredo J Bras Pneumol Original Article OBJECTIVE: To describe the trends in tumor histology, gender and age among patients with non-small cell lung cancer (NSCLC) treated with lung resection. The histology of lung cancer has changed in developed countries, and there is still little information available on the topic for developing countries. METHODS: This was a retrospective study of 1,030 patients with NSCLC treated with lung resection between 1986 and 2015 at a university hospital in southern Brazil. Differences in histology, stage, and type of surgery were analyzed by gender and for three periods (1986-1995, 1996-2005, and 2006-2015). RESULTS: Most (64.5%) of the patients were males, and the main histological types were squamous cell carcinoma (in 40.6%) and adenocarcinoma (in 44.5%). The mean age at surgery during the first period was 56.4 years for women and 58.9 years for men, compared with 62.2 for women and 64.6 for men in the third period (p < 0.001). The proportion of females increased from 26.6% in the first period to 44.1% in the third. From the first to the third period, the proportion of patients with squamous cell carcinoma decreased from 49.6% to 34.8% overall (p < 0.001), decreasing to an even greater degree (from 38.9% to 23.2%) among men. Among the NSCLC patients in our sample, females with adenocarcinoma accounted for 11.9% in the first period and 24.0% in the third period (p < 0.001). CONCLUSIONS: As has been seen in developed countries, the rates of lung cancer in females in southern Brazil have been rising over the last three decades, although they have yet to surpass those observed for males in the region. The incidence of squamous cell carcinoma has decreased in males, approaching adenocarcinoma rates, whereas adenocarcinoma has significantly increased among women. Sociedade Brasileira de Pneumologia e Tisiologia 2017 /pmc/articles/PMC5790654/ /pubmed/29160382 http://dx.doi.org/10.1590/S1806-37562016000000339 Text en Copyright © 2017 Sociedade Brasileira de Pneumologia e Tisiologia http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License |
spellingShingle | Original Article Tsukazan, Maria Teresa Ruiz Vigo, Álvaro da Silva, Vinícius Duval Barrios, Carlos Henrique Rios, Jayme de Oliveira Pinto, José Antônio de Figueiredo Lung cancer: changes in histology, gender, and age over the last 30 years in Brazil |
title | Lung cancer: changes in histology, gender, and age over the last 30 years in Brazil |
title_full | Lung cancer: changes in histology, gender, and age over the last 30 years in Brazil |
title_fullStr | Lung cancer: changes in histology, gender, and age over the last 30 years in Brazil |
title_full_unstemmed | Lung cancer: changes in histology, gender, and age over the last 30 years in Brazil |
title_short | Lung cancer: changes in histology, gender, and age over the last 30 years in Brazil |
title_sort | lung cancer: changes in histology, gender, and age over the last 30 years in brazil |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790654/ https://www.ncbi.nlm.nih.gov/pubmed/29160382 http://dx.doi.org/10.1590/S1806-37562016000000339 |
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