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Lung cancer: changes in histology, gender, and age over the last 30 years in Brazil

OBJECTIVE: To describe the trends in tumor histology, gender and age among patients with non-small cell lung cancer (NSCLC) treated with lung resection. The histology of lung cancer has changed in developed countries, and there is still little information available on the topic for developing countr...

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Autores principales: Tsukazan, Maria Teresa Ruiz, Vigo, Álvaro, da Silva, Vinícius Duval, Barrios, Carlos Henrique, Rios, Jayme de Oliveira, Pinto, José Antônio de Figueiredo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Pneumologia e Tisiologia 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790654/
https://www.ncbi.nlm.nih.gov/pubmed/29160382
http://dx.doi.org/10.1590/S1806-37562016000000339
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author Tsukazan, Maria Teresa Ruiz
Vigo, Álvaro
da Silva, Vinícius Duval
Barrios, Carlos Henrique
Rios, Jayme de Oliveira
Pinto, José Antônio de Figueiredo
author_facet Tsukazan, Maria Teresa Ruiz
Vigo, Álvaro
da Silva, Vinícius Duval
Barrios, Carlos Henrique
Rios, Jayme de Oliveira
Pinto, José Antônio de Figueiredo
author_sort Tsukazan, Maria Teresa Ruiz
collection PubMed
description OBJECTIVE: To describe the trends in tumor histology, gender and age among patients with non-small cell lung cancer (NSCLC) treated with lung resection. The histology of lung cancer has changed in developed countries, and there is still little information available on the topic for developing countries. METHODS: This was a retrospective study of 1,030 patients with NSCLC treated with lung resection between 1986 and 2015 at a university hospital in southern Brazil. Differences in histology, stage, and type of surgery were analyzed by gender and for three periods (1986-1995, 1996-2005, and 2006-2015). RESULTS: Most (64.5%) of the patients were males, and the main histological types were squamous cell carcinoma (in 40.6%) and adenocarcinoma (in 44.5%). The mean age at surgery during the first period was 56.4 years for women and 58.9 years for men, compared with 62.2 for women and 64.6 for men in the third period (p < 0.001). The proportion of females increased from 26.6% in the first period to 44.1% in the third. From the first to the third period, the proportion of patients with squamous cell carcinoma decreased from 49.6% to 34.8% overall (p < 0.001), decreasing to an even greater degree (from 38.9% to 23.2%) among men. Among the NSCLC patients in our sample, females with adenocarcinoma accounted for 11.9% in the first period and 24.0% in the third period (p < 0.001). CONCLUSIONS: As has been seen in developed countries, the rates of lung cancer in females in southern Brazil have been rising over the last three decades, although they have yet to surpass those observed for males in the region. The incidence of squamous cell carcinoma has decreased in males, approaching adenocarcinoma rates, whereas adenocarcinoma has significantly increased among women.
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spelling pubmed-57906542018-02-08 Lung cancer: changes in histology, gender, and age over the last 30 years in Brazil Tsukazan, Maria Teresa Ruiz Vigo, Álvaro da Silva, Vinícius Duval Barrios, Carlos Henrique Rios, Jayme de Oliveira Pinto, José Antônio de Figueiredo J Bras Pneumol Original Article OBJECTIVE: To describe the trends in tumor histology, gender and age among patients with non-small cell lung cancer (NSCLC) treated with lung resection. The histology of lung cancer has changed in developed countries, and there is still little information available on the topic for developing countries. METHODS: This was a retrospective study of 1,030 patients with NSCLC treated with lung resection between 1986 and 2015 at a university hospital in southern Brazil. Differences in histology, stage, and type of surgery were analyzed by gender and for three periods (1986-1995, 1996-2005, and 2006-2015). RESULTS: Most (64.5%) of the patients were males, and the main histological types were squamous cell carcinoma (in 40.6%) and adenocarcinoma (in 44.5%). The mean age at surgery during the first period was 56.4 years for women and 58.9 years for men, compared with 62.2 for women and 64.6 for men in the third period (p < 0.001). The proportion of females increased from 26.6% in the first period to 44.1% in the third. From the first to the third period, the proportion of patients with squamous cell carcinoma decreased from 49.6% to 34.8% overall (p < 0.001), decreasing to an even greater degree (from 38.9% to 23.2%) among men. Among the NSCLC patients in our sample, females with adenocarcinoma accounted for 11.9% in the first period and 24.0% in the third period (p < 0.001). CONCLUSIONS: As has been seen in developed countries, the rates of lung cancer in females in southern Brazil have been rising over the last three decades, although they have yet to surpass those observed for males in the region. The incidence of squamous cell carcinoma has decreased in males, approaching adenocarcinoma rates, whereas adenocarcinoma has significantly increased among women. Sociedade Brasileira de Pneumologia e Tisiologia 2017 /pmc/articles/PMC5790654/ /pubmed/29160382 http://dx.doi.org/10.1590/S1806-37562016000000339 Text en Copyright © 2017 Sociedade Brasileira de Pneumologia e Tisiologia http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Original Article
Tsukazan, Maria Teresa Ruiz
Vigo, Álvaro
da Silva, Vinícius Duval
Barrios, Carlos Henrique
Rios, Jayme de Oliveira
Pinto, José Antônio de Figueiredo
Lung cancer: changes in histology, gender, and age over the last 30 years in Brazil
title Lung cancer: changes in histology, gender, and age over the last 30 years in Brazil
title_full Lung cancer: changes in histology, gender, and age over the last 30 years in Brazil
title_fullStr Lung cancer: changes in histology, gender, and age over the last 30 years in Brazil
title_full_unstemmed Lung cancer: changes in histology, gender, and age over the last 30 years in Brazil
title_short Lung cancer: changes in histology, gender, and age over the last 30 years in Brazil
title_sort lung cancer: changes in histology, gender, and age over the last 30 years in brazil
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790654/
https://www.ncbi.nlm.nih.gov/pubmed/29160382
http://dx.doi.org/10.1590/S1806-37562016000000339
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