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Effects of continuous positive airway pressure on blood pressure in patients with resistant hypertension and obstructive sleep apnea: a systematic review and meta-analysis of six randomized controlled trials
OBJECTIVE: To evaluate systematically the effects of continuous positive airway pressure (CPAP) on blood pressure in patients with resistant hypertension and obstructive sleep apnea (OSA). METHODS: The Cochrane Library, PubMed, ScienceDirect, and the Web of Science were searched for studies investig...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Pneumologia e Tisiologia
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790661/ https://www.ncbi.nlm.nih.gov/pubmed/28767770 http://dx.doi.org/10.1590/S1806-37562016000000190 |
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author | Lei, Qiang Lv, Yunhui Li, Kai Ma, Lei Du, Guodong Xiang, Yan Li, Xuqing |
author_facet | Lei, Qiang Lv, Yunhui Li, Kai Ma, Lei Du, Guodong Xiang, Yan Li, Xuqing |
author_sort | Lei, Qiang |
collection | PubMed |
description | OBJECTIVE: To evaluate systematically the effects of continuous positive airway pressure (CPAP) on blood pressure in patients with resistant hypertension and obstructive sleep apnea (OSA). METHODS: The Cochrane Library, PubMed, ScienceDirect, and the Web of Science were searched for studies investigating the effects of CPAP on blood pressure in patients with resistant hypertension and OSA. The selected studies underwent quality assessment and meta-analysis, as well as being tested for heterogeneity. RESULTS: Six randomized controlled trials were included in the meta-analysis. The pooled estimates of the changes in mean systolic blood pressure and mean diastolic blood pressure (as assessed by 24-h ambulatory blood pressure monitoring) were −5.40 mmHg (95% CI: −9.17 to −1.64; p = 0.001; I(2) = 74%) and −3.86 mmHg (95% CI: −6.41 to −1.30; p = 0.00001; I(2) = 79%), respectively. CONCLUSIONS: CPAP therapy can significantly reduce blood pressure in patients with resistant hypertension and OSA. |
format | Online Article Text |
id | pubmed-5790661 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Sociedade Brasileira de Pneumologia e Tisiologia |
record_format | MEDLINE/PubMed |
spelling | pubmed-57906612018-02-08 Effects of continuous positive airway pressure on blood pressure in patients with resistant hypertension and obstructive sleep apnea: a systematic review and meta-analysis of six randomized controlled trials Lei, Qiang Lv, Yunhui Li, Kai Ma, Lei Du, Guodong Xiang, Yan Li, Xuqing J Bras Pneumol Meta-Analysis OBJECTIVE: To evaluate systematically the effects of continuous positive airway pressure (CPAP) on blood pressure in patients with resistant hypertension and obstructive sleep apnea (OSA). METHODS: The Cochrane Library, PubMed, ScienceDirect, and the Web of Science were searched for studies investigating the effects of CPAP on blood pressure in patients with resistant hypertension and OSA. The selected studies underwent quality assessment and meta-analysis, as well as being tested for heterogeneity. RESULTS: Six randomized controlled trials were included in the meta-analysis. The pooled estimates of the changes in mean systolic blood pressure and mean diastolic blood pressure (as assessed by 24-h ambulatory blood pressure monitoring) were −5.40 mmHg (95% CI: −9.17 to −1.64; p = 0.001; I(2) = 74%) and −3.86 mmHg (95% CI: −6.41 to −1.30; p = 0.00001; I(2) = 79%), respectively. CONCLUSIONS: CPAP therapy can significantly reduce blood pressure in patients with resistant hypertension and OSA. Sociedade Brasileira de Pneumologia e Tisiologia 2017 /pmc/articles/PMC5790661/ /pubmed/28767770 http://dx.doi.org/10.1590/S1806-37562016000000190 Text en Copyright © 2017 Sociedade Brasileira de Pneumologia e Tisiologia http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License |
spellingShingle | Meta-Analysis Lei, Qiang Lv, Yunhui Li, Kai Ma, Lei Du, Guodong Xiang, Yan Li, Xuqing Effects of continuous positive airway pressure on blood pressure in patients with resistant hypertension and obstructive sleep apnea: a systematic review and meta-analysis of six randomized controlled trials |
title | Effects of continuous positive airway pressure on blood pressure in patients with resistant hypertension and obstructive sleep apnea: a systematic review and meta-analysis of six randomized controlled trials |
title_full | Effects of continuous positive airway pressure on blood pressure in patients with resistant hypertension and obstructive sleep apnea: a systematic review and meta-analysis of six randomized controlled trials |
title_fullStr | Effects of continuous positive airway pressure on blood pressure in patients with resistant hypertension and obstructive sleep apnea: a systematic review and meta-analysis of six randomized controlled trials |
title_full_unstemmed | Effects of continuous positive airway pressure on blood pressure in patients with resistant hypertension and obstructive sleep apnea: a systematic review and meta-analysis of six randomized controlled trials |
title_short | Effects of continuous positive airway pressure on blood pressure in patients with resistant hypertension and obstructive sleep apnea: a systematic review and meta-analysis of six randomized controlled trials |
title_sort | effects of continuous positive airway pressure on blood pressure in patients with resistant hypertension and obstructive sleep apnea: a systematic review and meta-analysis of six randomized controlled trials |
topic | Meta-Analysis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790661/ https://www.ncbi.nlm.nih.gov/pubmed/28767770 http://dx.doi.org/10.1590/S1806-37562016000000190 |
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