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Effects of continuous positive airway pressure on blood pressure in patients with resistant hypertension and obstructive sleep apnea: a systematic review and meta-analysis of six randomized controlled trials

OBJECTIVE: To evaluate systematically the effects of continuous positive airway pressure (CPAP) on blood pressure in patients with resistant hypertension and obstructive sleep apnea (OSA). METHODS: The Cochrane Library, PubMed, ScienceDirect, and the Web of Science were searched for studies investig...

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Autores principales: Lei, Qiang, Lv, Yunhui, Li, Kai, Ma, Lei, Du, Guodong, Xiang, Yan, Li, Xuqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Pneumologia e Tisiologia 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790661/
https://www.ncbi.nlm.nih.gov/pubmed/28767770
http://dx.doi.org/10.1590/S1806-37562016000000190
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author Lei, Qiang
Lv, Yunhui
Li, Kai
Ma, Lei
Du, Guodong
Xiang, Yan
Li, Xuqing
author_facet Lei, Qiang
Lv, Yunhui
Li, Kai
Ma, Lei
Du, Guodong
Xiang, Yan
Li, Xuqing
author_sort Lei, Qiang
collection PubMed
description OBJECTIVE: To evaluate systematically the effects of continuous positive airway pressure (CPAP) on blood pressure in patients with resistant hypertension and obstructive sleep apnea (OSA). METHODS: The Cochrane Library, PubMed, ScienceDirect, and the Web of Science were searched for studies investigating the effects of CPAP on blood pressure in patients with resistant hypertension and OSA. The selected studies underwent quality assessment and meta-analysis, as well as being tested for heterogeneity. RESULTS: Six randomized controlled trials were included in the meta-analysis. The pooled estimates of the changes in mean systolic blood pressure and mean diastolic blood pressure (as assessed by 24-h ambulatory blood pressure monitoring) were −5.40 mmHg (95% CI: −9.17 to −1.64; p = 0.001; I(2) = 74%) and −3.86 mmHg (95% CI: −6.41 to −1.30; p = 0.00001; I(2) = 79%), respectively. CONCLUSIONS: CPAP therapy can significantly reduce blood pressure in patients with resistant hypertension and OSA.
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spelling pubmed-57906612018-02-08 Effects of continuous positive airway pressure on blood pressure in patients with resistant hypertension and obstructive sleep apnea: a systematic review and meta-analysis of six randomized controlled trials Lei, Qiang Lv, Yunhui Li, Kai Ma, Lei Du, Guodong Xiang, Yan Li, Xuqing J Bras Pneumol Meta-Analysis OBJECTIVE: To evaluate systematically the effects of continuous positive airway pressure (CPAP) on blood pressure in patients with resistant hypertension and obstructive sleep apnea (OSA). METHODS: The Cochrane Library, PubMed, ScienceDirect, and the Web of Science were searched for studies investigating the effects of CPAP on blood pressure in patients with resistant hypertension and OSA. The selected studies underwent quality assessment and meta-analysis, as well as being tested for heterogeneity. RESULTS: Six randomized controlled trials were included in the meta-analysis. The pooled estimates of the changes in mean systolic blood pressure and mean diastolic blood pressure (as assessed by 24-h ambulatory blood pressure monitoring) were −5.40 mmHg (95% CI: −9.17 to −1.64; p = 0.001; I(2) = 74%) and −3.86 mmHg (95% CI: −6.41 to −1.30; p = 0.00001; I(2) = 79%), respectively. CONCLUSIONS: CPAP therapy can significantly reduce blood pressure in patients with resistant hypertension and OSA. Sociedade Brasileira de Pneumologia e Tisiologia 2017 /pmc/articles/PMC5790661/ /pubmed/28767770 http://dx.doi.org/10.1590/S1806-37562016000000190 Text en Copyright © 2017 Sociedade Brasileira de Pneumologia e Tisiologia http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Meta-Analysis
Lei, Qiang
Lv, Yunhui
Li, Kai
Ma, Lei
Du, Guodong
Xiang, Yan
Li, Xuqing
Effects of continuous positive airway pressure on blood pressure in patients with resistant hypertension and obstructive sleep apnea: a systematic review and meta-analysis of six randomized controlled trials
title Effects of continuous positive airway pressure on blood pressure in patients with resistant hypertension and obstructive sleep apnea: a systematic review and meta-analysis of six randomized controlled trials
title_full Effects of continuous positive airway pressure on blood pressure in patients with resistant hypertension and obstructive sleep apnea: a systematic review and meta-analysis of six randomized controlled trials
title_fullStr Effects of continuous positive airway pressure on blood pressure in patients with resistant hypertension and obstructive sleep apnea: a systematic review and meta-analysis of six randomized controlled trials
title_full_unstemmed Effects of continuous positive airway pressure on blood pressure in patients with resistant hypertension and obstructive sleep apnea: a systematic review and meta-analysis of six randomized controlled trials
title_short Effects of continuous positive airway pressure on blood pressure in patients with resistant hypertension and obstructive sleep apnea: a systematic review and meta-analysis of six randomized controlled trials
title_sort effects of continuous positive airway pressure on blood pressure in patients with resistant hypertension and obstructive sleep apnea: a systematic review and meta-analysis of six randomized controlled trials
topic Meta-Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790661/
https://www.ncbi.nlm.nih.gov/pubmed/28767770
http://dx.doi.org/10.1590/S1806-37562016000000190
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