Cargando…

Electrochemical determination of an anti-hyperlipidimic drug pitavastatin at electrochemical sensor based on electrochemically pre-treated polymer film modified GCE

An electrochemically pretreated silver macroporous (Ag MP) multiwalled carbon nanotube modified glassy carbon electrode (PAN-Ag MP-MWCNT-GCE) was fabricated for the selective determination of an anti-hyperlipidimic drug, pitavastatin (PST). The fabricated electrochemical sensor was characterized by...

Descripción completa

Detalles Bibliográficos
Autores principales: Pandit, Umar J., Naikoo, Gowhar A., Sheikh, Mehraj Ud Din, Khan, Gulzar A., Raj, K.K., Limaye, S.N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790704/
https://www.ncbi.nlm.nih.gov/pubmed/29404047
http://dx.doi.org/10.1016/j.jpha.2017.03.002
_version_ 1783296491409899520
author Pandit, Umar J.
Naikoo, Gowhar A.
Sheikh, Mehraj Ud Din
Khan, Gulzar A.
Raj, K.K.
Limaye, S.N.
author_facet Pandit, Umar J.
Naikoo, Gowhar A.
Sheikh, Mehraj Ud Din
Khan, Gulzar A.
Raj, K.K.
Limaye, S.N.
author_sort Pandit, Umar J.
collection PubMed
description An electrochemically pretreated silver macroporous (Ag MP) multiwalled carbon nanotube modified glassy carbon electrode (PAN-Ag MP-MWCNT-GCE) was fabricated for the selective determination of an anti-hyperlipidimic drug, pitavastatin (PST). The fabricated electrochemical sensor was characterized by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The fabricated electrode was employed in quantifying and determining PST through differential pulse adsorptive stripping voltammetry (DPAdSV) and CV. The electrode fabrication proceeded with remarkable sensitivity to the determination of PST. The effect of various optimized parameters such as pH, scan rate (ν), accumulation time (t(acc)), accumulation potential (U(acc)) and loading volumes of Ag MP-MWCNT suspension were investigated to evaluate the performance of synthesized electrochemical sensor and to propose a simple, accurate, rapid and economical procedure for the quantification of PST in pharmaceutical formulations and biological fluids. A linear response of PST concentration in the range 2.0×10(−7)–1.6×10(−6) M with low detection (LOD) and quantification (LOQ) limits of 9.66±0.04 nM and 32.25±0.07 nM, respectively, were obtained under these optimized conditions.
format Online
Article
Text
id pubmed-5790704
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Xi'an Jiaotong University
record_format MEDLINE/PubMed
spelling pubmed-57907042018-02-05 Electrochemical determination of an anti-hyperlipidimic drug pitavastatin at electrochemical sensor based on electrochemically pre-treated polymer film modified GCE Pandit, Umar J. Naikoo, Gowhar A. Sheikh, Mehraj Ud Din Khan, Gulzar A. Raj, K.K. Limaye, S.N. J Pharm Anal Original Research Article An electrochemically pretreated silver macroporous (Ag MP) multiwalled carbon nanotube modified glassy carbon electrode (PAN-Ag MP-MWCNT-GCE) was fabricated for the selective determination of an anti-hyperlipidimic drug, pitavastatin (PST). The fabricated electrochemical sensor was characterized by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The fabricated electrode was employed in quantifying and determining PST through differential pulse adsorptive stripping voltammetry (DPAdSV) and CV. The electrode fabrication proceeded with remarkable sensitivity to the determination of PST. The effect of various optimized parameters such as pH, scan rate (ν), accumulation time (t(acc)), accumulation potential (U(acc)) and loading volumes of Ag MP-MWCNT suspension were investigated to evaluate the performance of synthesized electrochemical sensor and to propose a simple, accurate, rapid and economical procedure for the quantification of PST in pharmaceutical formulations and biological fluids. A linear response of PST concentration in the range 2.0×10(−7)–1.6×10(−6) M with low detection (LOD) and quantification (LOQ) limits of 9.66±0.04 nM and 32.25±0.07 nM, respectively, were obtained under these optimized conditions. Xi'an Jiaotong University 2017-08 2017-03-19 /pmc/articles/PMC5790704/ /pubmed/29404047 http://dx.doi.org/10.1016/j.jpha.2017.03.002 Text en © 2017 Xi'an Jiaotong University. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research Article
Pandit, Umar J.
Naikoo, Gowhar A.
Sheikh, Mehraj Ud Din
Khan, Gulzar A.
Raj, K.K.
Limaye, S.N.
Electrochemical determination of an anti-hyperlipidimic drug pitavastatin at electrochemical sensor based on electrochemically pre-treated polymer film modified GCE
title Electrochemical determination of an anti-hyperlipidimic drug pitavastatin at electrochemical sensor based on electrochemically pre-treated polymer film modified GCE
title_full Electrochemical determination of an anti-hyperlipidimic drug pitavastatin at electrochemical sensor based on electrochemically pre-treated polymer film modified GCE
title_fullStr Electrochemical determination of an anti-hyperlipidimic drug pitavastatin at electrochemical sensor based on electrochemically pre-treated polymer film modified GCE
title_full_unstemmed Electrochemical determination of an anti-hyperlipidimic drug pitavastatin at electrochemical sensor based on electrochemically pre-treated polymer film modified GCE
title_short Electrochemical determination of an anti-hyperlipidimic drug pitavastatin at electrochemical sensor based on electrochemically pre-treated polymer film modified GCE
title_sort electrochemical determination of an anti-hyperlipidimic drug pitavastatin at electrochemical sensor based on electrochemically pre-treated polymer film modified gce
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790704/
https://www.ncbi.nlm.nih.gov/pubmed/29404047
http://dx.doi.org/10.1016/j.jpha.2017.03.002
work_keys_str_mv AT panditumarj electrochemicaldeterminationofanantihyperlipidimicdrugpitavastatinatelectrochemicalsensorbasedonelectrochemicallypretreatedpolymerfilmmodifiedgce
AT naikoogowhara electrochemicaldeterminationofanantihyperlipidimicdrugpitavastatinatelectrochemicalsensorbasedonelectrochemicallypretreatedpolymerfilmmodifiedgce
AT sheikhmehrajuddin electrochemicaldeterminationofanantihyperlipidimicdrugpitavastatinatelectrochemicalsensorbasedonelectrochemicallypretreatedpolymerfilmmodifiedgce
AT khangulzara electrochemicaldeterminationofanantihyperlipidimicdrugpitavastatinatelectrochemicalsensorbasedonelectrochemicallypretreatedpolymerfilmmodifiedgce
AT rajkk electrochemicaldeterminationofanantihyperlipidimicdrugpitavastatinatelectrochemicalsensorbasedonelectrochemicallypretreatedpolymerfilmmodifiedgce
AT limayesn electrochemicaldeterminationofanantihyperlipidimicdrugpitavastatinatelectrochemicalsensorbasedonelectrochemicallypretreatedpolymerfilmmodifiedgce