Cargando…

Management of Osteoporosis in Chronic Kidney Disease

Chronic kidney disease (CKD) patients with coexisting osteoporosis are becoming common. Many of the therapeutic agents used to treat osteoporosis are known to be affected by the renal function. It is generally thought that osteoporosis in G1 to G3 CKD patients can be treated as in non-CKD patients w...

Descripción completa

Detalles Bibliográficos
Autores principales: Nitta, Kosaku, Yajima, Aiji, Tsuchiya, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790712/
https://www.ncbi.nlm.nih.gov/pubmed/29021477
http://dx.doi.org/10.2169/internalmedicine.8618-16
_version_ 1783296493255393280
author Nitta, Kosaku
Yajima, Aiji
Tsuchiya, Ken
author_facet Nitta, Kosaku
Yajima, Aiji
Tsuchiya, Ken
author_sort Nitta, Kosaku
collection PubMed
description Chronic kidney disease (CKD) patients with coexisting osteoporosis are becoming common. Many of the therapeutic agents used to treat osteoporosis are known to be affected by the renal function. It is generally thought that osteoporosis in G1 to G3 CKD patients can be treated as in non-CKD patients with osteoporosis. In stage 4 or more advanced CKD patients and CKD patients on dialysis with osteoporosis, however, bisphosphonates must be used with caution, bearing in mind the potential development of such disorders as adynamic bone disease. The use of vitamin D preparations in low doses is relatively safe. In postmenopausal women, raloxifene must be administered with caution. When using denosumab, the serum calcium concentrations should be monitored carefully to prevent the development of hypocalcemia, and active vitamin D preparations should be administered concomitantly. The present article provides an overview of the management of osteoporosis in CKD patients.
format Online
Article
Text
id pubmed-5790712
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher The Japanese Society of Internal Medicine
record_format MEDLINE/PubMed
spelling pubmed-57907122018-01-31 Management of Osteoporosis in Chronic Kidney Disease Nitta, Kosaku Yajima, Aiji Tsuchiya, Ken Intern Med Review Article Chronic kidney disease (CKD) patients with coexisting osteoporosis are becoming common. Many of the therapeutic agents used to treat osteoporosis are known to be affected by the renal function. It is generally thought that osteoporosis in G1 to G3 CKD patients can be treated as in non-CKD patients with osteoporosis. In stage 4 or more advanced CKD patients and CKD patients on dialysis with osteoporosis, however, bisphosphonates must be used with caution, bearing in mind the potential development of such disorders as adynamic bone disease. The use of vitamin D preparations in low doses is relatively safe. In postmenopausal women, raloxifene must be administered with caution. When using denosumab, the serum calcium concentrations should be monitored carefully to prevent the development of hypocalcemia, and active vitamin D preparations should be administered concomitantly. The present article provides an overview of the management of osteoporosis in CKD patients. The Japanese Society of Internal Medicine 2017-10-11 2017-12-15 /pmc/articles/PMC5790712/ /pubmed/29021477 http://dx.doi.org/10.2169/internalmedicine.8618-16 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Nitta, Kosaku
Yajima, Aiji
Tsuchiya, Ken
Management of Osteoporosis in Chronic Kidney Disease
title Management of Osteoporosis in Chronic Kidney Disease
title_full Management of Osteoporosis in Chronic Kidney Disease
title_fullStr Management of Osteoporosis in Chronic Kidney Disease
title_full_unstemmed Management of Osteoporosis in Chronic Kidney Disease
title_short Management of Osteoporosis in Chronic Kidney Disease
title_sort management of osteoporosis in chronic kidney disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790712/
https://www.ncbi.nlm.nih.gov/pubmed/29021477
http://dx.doi.org/10.2169/internalmedicine.8618-16
work_keys_str_mv AT nittakosaku managementofosteoporosisinchronickidneydisease
AT yajimaaiji managementofosteoporosisinchronickidneydisease
AT tsuchiyaken managementofosteoporosisinchronickidneydisease