Familial Adenomatous Polyposis with Multiple Helicobacter-negative Early Gastric Cancers Treated by Endoscopic Submucosal Dissection

Stomach cancer rarely develops in patients with familial adenomatous polyposis (FAP), and Helicobacter pylori infection may increase the risk of FAP-related gastric cancer. We describe the case of a 64-year-old woman who developed multiple synchronous early gastric cancers without H. pylori infectio...

Descripción completa

Detalles Bibliográficos
Autores principales: Yaguchi, Katsuki, Makazu, Makomo, Hirasawa, Kingo, Sugimori, Makoto, Kobayashi, Ryosuke, Sato, Chiko, Ikeda, Ryosuke, Fukuchi, Takehide, Ishii, Yasuaki, Kaneko, Hiroaki, Shibata, Wataru, Yamanaka, Shoji, Inayama, Yoshiaki, Maeda, Shin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790714/
https://www.ncbi.nlm.nih.gov/pubmed/29021452
http://dx.doi.org/10.2169/internalmedicine.8735-16
Descripción
Sumario:Stomach cancer rarely develops in patients with familial adenomatous polyposis (FAP), and Helicobacter pylori infection may increase the risk of FAP-related gastric cancer. We describe the case of a 64-year-old woman who developed multiple synchronous early gastric cancers without H. pylori infection. Nine cancer lesions were successfully treated by endoscopic submucosal dissection. An immunohistochemical analysis revealed that the tumors were positive for mucin (MUC)2, MUC6, and CDX2, but negative for MUC5AC, suggesting that the tumors were gastrointestinal mixed type. Periodical endoscopic surveillance is important for the detection of cancers at an early stage.

Ejemplares similares