Familial Adenomatous Polyposis with Multiple Helicobacter-negative Early Gastric Cancers Treated by Endoscopic Submucosal Dissection

Stomach cancer rarely develops in patients with familial adenomatous polyposis (FAP), and Helicobacter pylori infection may increase the risk of FAP-related gastric cancer. We describe the case of a 64-year-old woman who developed multiple synchronous early gastric cancers without H. pylori infectio...

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Autores principales: Yaguchi, Katsuki, Makazu, Makomo, Hirasawa, Kingo, Sugimori, Makoto, Kobayashi, Ryosuke, Sato, Chiko, Ikeda, Ryosuke, Fukuchi, Takehide, Ishii, Yasuaki, Kaneko, Hiroaki, Shibata, Wataru, Yamanaka, Shoji, Inayama, Yoshiaki, Maeda, Shin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790714/
https://www.ncbi.nlm.nih.gov/pubmed/29021452
http://dx.doi.org/10.2169/internalmedicine.8735-16
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author Yaguchi, Katsuki
Makazu, Makomo
Hirasawa, Kingo
Sugimori, Makoto
Kobayashi, Ryosuke
Sato, Chiko
Ikeda, Ryosuke
Fukuchi, Takehide
Ishii, Yasuaki
Kaneko, Hiroaki
Shibata, Wataru
Yamanaka, Shoji
Inayama, Yoshiaki
Maeda, Shin
author_facet Yaguchi, Katsuki
Makazu, Makomo
Hirasawa, Kingo
Sugimori, Makoto
Kobayashi, Ryosuke
Sato, Chiko
Ikeda, Ryosuke
Fukuchi, Takehide
Ishii, Yasuaki
Kaneko, Hiroaki
Shibata, Wataru
Yamanaka, Shoji
Inayama, Yoshiaki
Maeda, Shin
author_sort Yaguchi, Katsuki
collection PubMed
description Stomach cancer rarely develops in patients with familial adenomatous polyposis (FAP), and Helicobacter pylori infection may increase the risk of FAP-related gastric cancer. We describe the case of a 64-year-old woman who developed multiple synchronous early gastric cancers without H. pylori infection. Nine cancer lesions were successfully treated by endoscopic submucosal dissection. An immunohistochemical analysis revealed that the tumors were positive for mucin (MUC)2, MUC6, and CDX2, but negative for MUC5AC, suggesting that the tumors were gastrointestinal mixed type. Periodical endoscopic surveillance is important for the detection of cancers at an early stage.
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spelling pubmed-57907142018-01-31 Familial Adenomatous Polyposis with Multiple Helicobacter-negative Early Gastric Cancers Treated by Endoscopic Submucosal Dissection Yaguchi, Katsuki Makazu, Makomo Hirasawa, Kingo Sugimori, Makoto Kobayashi, Ryosuke Sato, Chiko Ikeda, Ryosuke Fukuchi, Takehide Ishii, Yasuaki Kaneko, Hiroaki Shibata, Wataru Yamanaka, Shoji Inayama, Yoshiaki Maeda, Shin Intern Med Case Report Stomach cancer rarely develops in patients with familial adenomatous polyposis (FAP), and Helicobacter pylori infection may increase the risk of FAP-related gastric cancer. We describe the case of a 64-year-old woman who developed multiple synchronous early gastric cancers without H. pylori infection. Nine cancer lesions were successfully treated by endoscopic submucosal dissection. An immunohistochemical analysis revealed that the tumors were positive for mucin (MUC)2, MUC6, and CDX2, but negative for MUC5AC, suggesting that the tumors were gastrointestinal mixed type. Periodical endoscopic surveillance is important for the detection of cancers at an early stage. The Japanese Society of Internal Medicine 2017-10-11 2017-12-15 /pmc/articles/PMC5790714/ /pubmed/29021452 http://dx.doi.org/10.2169/internalmedicine.8735-16 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Yaguchi, Katsuki
Makazu, Makomo
Hirasawa, Kingo
Sugimori, Makoto
Kobayashi, Ryosuke
Sato, Chiko
Ikeda, Ryosuke
Fukuchi, Takehide
Ishii, Yasuaki
Kaneko, Hiroaki
Shibata, Wataru
Yamanaka, Shoji
Inayama, Yoshiaki
Maeda, Shin
Familial Adenomatous Polyposis with Multiple Helicobacter-negative Early Gastric Cancers Treated by Endoscopic Submucosal Dissection
title Familial Adenomatous Polyposis with Multiple Helicobacter-negative Early Gastric Cancers Treated by Endoscopic Submucosal Dissection
title_full Familial Adenomatous Polyposis with Multiple Helicobacter-negative Early Gastric Cancers Treated by Endoscopic Submucosal Dissection
title_fullStr Familial Adenomatous Polyposis with Multiple Helicobacter-negative Early Gastric Cancers Treated by Endoscopic Submucosal Dissection
title_full_unstemmed Familial Adenomatous Polyposis with Multiple Helicobacter-negative Early Gastric Cancers Treated by Endoscopic Submucosal Dissection
title_short Familial Adenomatous Polyposis with Multiple Helicobacter-negative Early Gastric Cancers Treated by Endoscopic Submucosal Dissection
title_sort familial adenomatous polyposis with multiple helicobacter-negative early gastric cancers treated by endoscopic submucosal dissection
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790714/
https://www.ncbi.nlm.nih.gov/pubmed/29021452
http://dx.doi.org/10.2169/internalmedicine.8735-16
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