Diffuse Intestinal Ganglioneuromatosis Showing Multiple Large Bowel Ulcers in a Patient with Neurofibromatosis Type 1

A 67-year-old Japanese man with neurofibromatosis type 1 underwent right hemicolectomy owing to abscess formation around the cecum. A pathological analysis revealed diffuse intestinal ganglioneuromatosis in the cecum and colon. Colonoscopy performed eight months after hemicolectomy revealed multiple...

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Autores principales: Iwamuro, Masaya, Omote, Rika, Tanaka, Takehiro, Sunada, Naruhiko, Nada, Takahiro, Kondo, Yoshitaka, Nose, Soichiro, Kawaguchi, Mitsuhiko, Otsuka, Fumio, Okada, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790715/
https://www.ncbi.nlm.nih.gov/pubmed/29021449
http://dx.doi.org/10.2169/internalmedicine.8671-16
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author Iwamuro, Masaya
Omote, Rika
Tanaka, Takehiro
Sunada, Naruhiko
Nada, Takahiro
Kondo, Yoshitaka
Nose, Soichiro
Kawaguchi, Mitsuhiko
Otsuka, Fumio
Okada, Hiroyuki
author_facet Iwamuro, Masaya
Omote, Rika
Tanaka, Takehiro
Sunada, Naruhiko
Nada, Takahiro
Kondo, Yoshitaka
Nose, Soichiro
Kawaguchi, Mitsuhiko
Otsuka, Fumio
Okada, Hiroyuki
author_sort Iwamuro, Masaya
collection PubMed
description A 67-year-old Japanese man with neurofibromatosis type 1 underwent right hemicolectomy owing to abscess formation around the cecum. A pathological analysis revealed diffuse intestinal ganglioneuromatosis in the cecum and colon. Colonoscopy performed eight months after hemicolectomy revealed multiple ulcers throughout the colon and rectum. The colorectal ulcers failed to respond to conservative treatment and ultimately required surgical resection. Diffuse ganglioneuromatosis was observed again in the resected specimen. This report illustrates a rare manifestation of diffuse intestinal ganglioneuromatosis in a patient with neurofibromatosis type 1.
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spelling pubmed-57907152018-01-31 Diffuse Intestinal Ganglioneuromatosis Showing Multiple Large Bowel Ulcers in a Patient with Neurofibromatosis Type 1 Iwamuro, Masaya Omote, Rika Tanaka, Takehiro Sunada, Naruhiko Nada, Takahiro Kondo, Yoshitaka Nose, Soichiro Kawaguchi, Mitsuhiko Otsuka, Fumio Okada, Hiroyuki Intern Med Case Report A 67-year-old Japanese man with neurofibromatosis type 1 underwent right hemicolectomy owing to abscess formation around the cecum. A pathological analysis revealed diffuse intestinal ganglioneuromatosis in the cecum and colon. Colonoscopy performed eight months after hemicolectomy revealed multiple ulcers throughout the colon and rectum. The colorectal ulcers failed to respond to conservative treatment and ultimately required surgical resection. Diffuse ganglioneuromatosis was observed again in the resected specimen. This report illustrates a rare manifestation of diffuse intestinal ganglioneuromatosis in a patient with neurofibromatosis type 1. The Japanese Society of Internal Medicine 2017-10-11 2017-12-15 /pmc/articles/PMC5790715/ /pubmed/29021449 http://dx.doi.org/10.2169/internalmedicine.8671-16 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Iwamuro, Masaya
Omote, Rika
Tanaka, Takehiro
Sunada, Naruhiko
Nada, Takahiro
Kondo, Yoshitaka
Nose, Soichiro
Kawaguchi, Mitsuhiko
Otsuka, Fumio
Okada, Hiroyuki
Diffuse Intestinal Ganglioneuromatosis Showing Multiple Large Bowel Ulcers in a Patient with Neurofibromatosis Type 1
title Diffuse Intestinal Ganglioneuromatosis Showing Multiple Large Bowel Ulcers in a Patient with Neurofibromatosis Type 1
title_full Diffuse Intestinal Ganglioneuromatosis Showing Multiple Large Bowel Ulcers in a Patient with Neurofibromatosis Type 1
title_fullStr Diffuse Intestinal Ganglioneuromatosis Showing Multiple Large Bowel Ulcers in a Patient with Neurofibromatosis Type 1
title_full_unstemmed Diffuse Intestinal Ganglioneuromatosis Showing Multiple Large Bowel Ulcers in a Patient with Neurofibromatosis Type 1
title_short Diffuse Intestinal Ganglioneuromatosis Showing Multiple Large Bowel Ulcers in a Patient with Neurofibromatosis Type 1
title_sort diffuse intestinal ganglioneuromatosis showing multiple large bowel ulcers in a patient with neurofibromatosis type 1
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790715/
https://www.ncbi.nlm.nih.gov/pubmed/29021449
http://dx.doi.org/10.2169/internalmedicine.8671-16
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