Severe Alcoholic Hepatitis Effectively Treated with Vitamin E as an Add-on to Corticosteroids

A 49-year-old woman with a history of heavy alcohol drinking was admitted to our hospital due to jaundice and abdominal distention. A blood test showed leukophilia, mild hypoalbuminemia, hyperbilirubinemia, hepatobiliary injury and coagulopathy. Image studies showed an extremely enlarged fatty liver...

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Autores principales: Miyashima, Yuichi, Shibata, Michihiko, Honma, Yuichi, Matsuoka, Hidehiko, Hiura, Masaaki, Abe, Shintaro, Harada, Masaru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790716/
https://www.ncbi.nlm.nih.gov/pubmed/29021453
http://dx.doi.org/10.2169/internalmedicine.8767-16
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author Miyashima, Yuichi
Shibata, Michihiko
Honma, Yuichi
Matsuoka, Hidehiko
Hiura, Masaaki
Abe, Shintaro
Harada, Masaru
author_facet Miyashima, Yuichi
Shibata, Michihiko
Honma, Yuichi
Matsuoka, Hidehiko
Hiura, Masaaki
Abe, Shintaro
Harada, Masaru
author_sort Miyashima, Yuichi
collection PubMed
description A 49-year-old woman with a history of heavy alcohol drinking was admitted to our hospital due to jaundice and abdominal distention. A blood test showed leukophilia, mild hypoalbuminemia, hyperbilirubinemia, hepatobiliary injury and coagulopathy. Image studies showed an extremely enlarged fatty liver and splenomegaly. The Japan alcoholic hepatitis score and Maddrey's discriminant function were 10 and 54 points, respectively. We diagnosed her with severe alcoholic hepatitis and treated her with corticosteroids, but her liver function did not improve. We therefore administered the vitamin E product tochopheryl acetate (150 mg/day) as an add-on therapy, after which her leukophilia, liver enzymes and coagulopathy improved immediately.
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spelling pubmed-57907162018-01-31 Severe Alcoholic Hepatitis Effectively Treated with Vitamin E as an Add-on to Corticosteroids Miyashima, Yuichi Shibata, Michihiko Honma, Yuichi Matsuoka, Hidehiko Hiura, Masaaki Abe, Shintaro Harada, Masaru Intern Med Case Report A 49-year-old woman with a history of heavy alcohol drinking was admitted to our hospital due to jaundice and abdominal distention. A blood test showed leukophilia, mild hypoalbuminemia, hyperbilirubinemia, hepatobiliary injury and coagulopathy. Image studies showed an extremely enlarged fatty liver and splenomegaly. The Japan alcoholic hepatitis score and Maddrey's discriminant function were 10 and 54 points, respectively. We diagnosed her with severe alcoholic hepatitis and treated her with corticosteroids, but her liver function did not improve. We therefore administered the vitamin E product tochopheryl acetate (150 mg/day) as an add-on therapy, after which her leukophilia, liver enzymes and coagulopathy improved immediately. The Japanese Society of Internal Medicine 2017-10-11 2017-12-15 /pmc/articles/PMC5790716/ /pubmed/29021453 http://dx.doi.org/10.2169/internalmedicine.8767-16 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Miyashima, Yuichi
Shibata, Michihiko
Honma, Yuichi
Matsuoka, Hidehiko
Hiura, Masaaki
Abe, Shintaro
Harada, Masaru
Severe Alcoholic Hepatitis Effectively Treated with Vitamin E as an Add-on to Corticosteroids
title Severe Alcoholic Hepatitis Effectively Treated with Vitamin E as an Add-on to Corticosteroids
title_full Severe Alcoholic Hepatitis Effectively Treated with Vitamin E as an Add-on to Corticosteroids
title_fullStr Severe Alcoholic Hepatitis Effectively Treated with Vitamin E as an Add-on to Corticosteroids
title_full_unstemmed Severe Alcoholic Hepatitis Effectively Treated with Vitamin E as an Add-on to Corticosteroids
title_short Severe Alcoholic Hepatitis Effectively Treated with Vitamin E as an Add-on to Corticosteroids
title_sort severe alcoholic hepatitis effectively treated with vitamin e as an add-on to corticosteroids
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790716/
https://www.ncbi.nlm.nih.gov/pubmed/29021453
http://dx.doi.org/10.2169/internalmedicine.8767-16
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