A Rare Monocytic Crisis of Chronic Myelogenous Leukemia Presenting with Unusual Extramedullary Manifestations and an Atypical (14;22)(q24;q11.2) Translocation in the Bone Marrow

A 48-year-old man was admitted due to marked leukocytosis. Bone marrow examinations resulted in a diagnosis of Philadelphia (Ph) chromosome-positive chronic myeloid leukemia. One month later, massive muscle and bone invasion by leukemic cells was detected. After induction chemotherapy, he complained...

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Detalles Bibliográficos
Autores principales: Inoue, Morihiro, Hagihara, Masao, Uchida, Tomoyuki, Hua, Jian, Nakajima, Takeshi, Tajima, Shogo, Ota, Yasunori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790724/
https://www.ncbi.nlm.nih.gov/pubmed/29021476
http://dx.doi.org/10.2169/internalmedicine.8617-16
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author Inoue, Morihiro
Hagihara, Masao
Uchida, Tomoyuki
Hua, Jian
Nakajima, Takeshi
Tajima, Shogo
Ota, Yasunori
author_facet Inoue, Morihiro
Hagihara, Masao
Uchida, Tomoyuki
Hua, Jian
Nakajima, Takeshi
Tajima, Shogo
Ota, Yasunori
author_sort Inoue, Morihiro
collection PubMed
description A 48-year-old man was admitted due to marked leukocytosis. Bone marrow examinations resulted in a diagnosis of Philadelphia (Ph) chromosome-positive chronic myeloid leukemia. One month later, massive muscle and bone invasion by leukemic cells was detected. After induction chemotherapy, he complained of a headache and visual loss, which was caused by a leukemic infiltration in the central nervous system. After temporary remission in response to chemotherapy, the disease relapsed in the form of an intracranial tumor. The unusual t(14;22)(q24;q11.2) translocation of the Ph-chromosome and the significant increase in monocytes observed might have contributed to the unique and aggressive clinical course.
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spelling pubmed-57907242018-01-31 A Rare Monocytic Crisis of Chronic Myelogenous Leukemia Presenting with Unusual Extramedullary Manifestations and an Atypical (14;22)(q24;q11.2) Translocation in the Bone Marrow Inoue, Morihiro Hagihara, Masao Uchida, Tomoyuki Hua, Jian Nakajima, Takeshi Tajima, Shogo Ota, Yasunori Intern Med Case Report A 48-year-old man was admitted due to marked leukocytosis. Bone marrow examinations resulted in a diagnosis of Philadelphia (Ph) chromosome-positive chronic myeloid leukemia. One month later, massive muscle and bone invasion by leukemic cells was detected. After induction chemotherapy, he complained of a headache and visual loss, which was caused by a leukemic infiltration in the central nervous system. After temporary remission in response to chemotherapy, the disease relapsed in the form of an intracranial tumor. The unusual t(14;22)(q24;q11.2) translocation of the Ph-chromosome and the significant increase in monocytes observed might have contributed to the unique and aggressive clinical course. The Japanese Society of Internal Medicine 2017-10-11 2017-12-15 /pmc/articles/PMC5790724/ /pubmed/29021476 http://dx.doi.org/10.2169/internalmedicine.8617-16 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Inoue, Morihiro
Hagihara, Masao
Uchida, Tomoyuki
Hua, Jian
Nakajima, Takeshi
Tajima, Shogo
Ota, Yasunori
A Rare Monocytic Crisis of Chronic Myelogenous Leukemia Presenting with Unusual Extramedullary Manifestations and an Atypical (14;22)(q24;q11.2) Translocation in the Bone Marrow
title A Rare Monocytic Crisis of Chronic Myelogenous Leukemia Presenting with Unusual Extramedullary Manifestations and an Atypical (14;22)(q24;q11.2) Translocation in the Bone Marrow
title_full A Rare Monocytic Crisis of Chronic Myelogenous Leukemia Presenting with Unusual Extramedullary Manifestations and an Atypical (14;22)(q24;q11.2) Translocation in the Bone Marrow
title_fullStr A Rare Monocytic Crisis of Chronic Myelogenous Leukemia Presenting with Unusual Extramedullary Manifestations and an Atypical (14;22)(q24;q11.2) Translocation in the Bone Marrow
title_full_unstemmed A Rare Monocytic Crisis of Chronic Myelogenous Leukemia Presenting with Unusual Extramedullary Manifestations and an Atypical (14;22)(q24;q11.2) Translocation in the Bone Marrow
title_short A Rare Monocytic Crisis of Chronic Myelogenous Leukemia Presenting with Unusual Extramedullary Manifestations and an Atypical (14;22)(q24;q11.2) Translocation in the Bone Marrow
title_sort rare monocytic crisis of chronic myelogenous leukemia presenting with unusual extramedullary manifestations and an atypical (14;22)(q24;q11.2) translocation in the bone marrow
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790724/
https://www.ncbi.nlm.nih.gov/pubmed/29021476
http://dx.doi.org/10.2169/internalmedicine.8617-16
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