Recurrent Kikuchi-Fujimoto Disease Successfully Treated by the Concomitant Use of Hydroxychloroquine and Corticosteroids

Kikuchi-Fujimoto disease (KFD) is a benign disease of unknown etiology characterized by lymphadenopathy and a fever. For the majority of patients with KFD, the course is self-limited; however, the optimum method of managing recurrent cases has not yet been established. We herein report a case of a 4...

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Detalles Bibliográficos
Autores principales: Honda, Fumika, Tsuboi, Hiroto, Toko, Hirofumi, Ohyama, Ayako, Takahashi, Hidenori, Abe, Saori, Yokosawa, Masahiro, Asashima, Hiromitsu, Hagiwara, Shinya, Hirota, Tomoya, Kondo, Yuya, Matsumoto, Isao, Sumida, Takayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790731/
https://www.ncbi.nlm.nih.gov/pubmed/29021444
http://dx.doi.org/10.2169/internalmedicine.9205-17
Descripción
Sumario:Kikuchi-Fujimoto disease (KFD) is a benign disease of unknown etiology characterized by lymphadenopathy and a fever. For the majority of patients with KFD, the course is self-limited; however, the optimum method of managing recurrent cases has not yet been established. We herein report a case of a 42-year-old Japanese woman with KFD (confirmed by a lymph node biopsy). Although high-dose prednisolone (PSL) rapidly induced remission, she experienced four recurrences on treatment tapering. Concomitant use of hydroxychloroquine (HCQ) with low-dose PSL induced continuous remission. This is the first case to suggest the effectiveness of HCQ for recurrent KFD in a Japanese patient.

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