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Recurrent Kikuchi-Fujimoto Disease Successfully Treated by the Concomitant Use of Hydroxychloroquine and Corticosteroids

Kikuchi-Fujimoto disease (KFD) is a benign disease of unknown etiology characterized by lymphadenopathy and a fever. For the majority of patients with KFD, the course is self-limited; however, the optimum method of managing recurrent cases has not yet been established. We herein report a case of a 4...

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Autores principales: Honda, Fumika, Tsuboi, Hiroto, Toko, Hirofumi, Ohyama, Ayako, Takahashi, Hidenori, Abe, Saori, Yokosawa, Masahiro, Asashima, Hiromitsu, Hagiwara, Shinya, Hirota, Tomoya, Kondo, Yuya, Matsumoto, Isao, Sumida, Takayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790731/
https://www.ncbi.nlm.nih.gov/pubmed/29021444
http://dx.doi.org/10.2169/internalmedicine.9205-17
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author Honda, Fumika
Tsuboi, Hiroto
Toko, Hirofumi
Ohyama, Ayako
Takahashi, Hidenori
Abe, Saori
Yokosawa, Masahiro
Asashima, Hiromitsu
Hagiwara, Shinya
Hirota, Tomoya
Kondo, Yuya
Matsumoto, Isao
Sumida, Takayuki
author_facet Honda, Fumika
Tsuboi, Hiroto
Toko, Hirofumi
Ohyama, Ayako
Takahashi, Hidenori
Abe, Saori
Yokosawa, Masahiro
Asashima, Hiromitsu
Hagiwara, Shinya
Hirota, Tomoya
Kondo, Yuya
Matsumoto, Isao
Sumida, Takayuki
author_sort Honda, Fumika
collection PubMed
description Kikuchi-Fujimoto disease (KFD) is a benign disease of unknown etiology characterized by lymphadenopathy and a fever. For the majority of patients with KFD, the course is self-limited; however, the optimum method of managing recurrent cases has not yet been established. We herein report a case of a 42-year-old Japanese woman with KFD (confirmed by a lymph node biopsy). Although high-dose prednisolone (PSL) rapidly induced remission, she experienced four recurrences on treatment tapering. Concomitant use of hydroxychloroquine (HCQ) with low-dose PSL induced continuous remission. This is the first case to suggest the effectiveness of HCQ for recurrent KFD in a Japanese patient.
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spelling pubmed-57907312018-01-31 Recurrent Kikuchi-Fujimoto Disease Successfully Treated by the Concomitant Use of Hydroxychloroquine and Corticosteroids Honda, Fumika Tsuboi, Hiroto Toko, Hirofumi Ohyama, Ayako Takahashi, Hidenori Abe, Saori Yokosawa, Masahiro Asashima, Hiromitsu Hagiwara, Shinya Hirota, Tomoya Kondo, Yuya Matsumoto, Isao Sumida, Takayuki Intern Med Case Report Kikuchi-Fujimoto disease (KFD) is a benign disease of unknown etiology characterized by lymphadenopathy and a fever. For the majority of patients with KFD, the course is self-limited; however, the optimum method of managing recurrent cases has not yet been established. We herein report a case of a 42-year-old Japanese woman with KFD (confirmed by a lymph node biopsy). Although high-dose prednisolone (PSL) rapidly induced remission, she experienced four recurrences on treatment tapering. Concomitant use of hydroxychloroquine (HCQ) with low-dose PSL induced continuous remission. This is the first case to suggest the effectiveness of HCQ for recurrent KFD in a Japanese patient. The Japanese Society of Internal Medicine 2017-10-11 2017-12-15 /pmc/articles/PMC5790731/ /pubmed/29021444 http://dx.doi.org/10.2169/internalmedicine.9205-17 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Honda, Fumika
Tsuboi, Hiroto
Toko, Hirofumi
Ohyama, Ayako
Takahashi, Hidenori
Abe, Saori
Yokosawa, Masahiro
Asashima, Hiromitsu
Hagiwara, Shinya
Hirota, Tomoya
Kondo, Yuya
Matsumoto, Isao
Sumida, Takayuki
Recurrent Kikuchi-Fujimoto Disease Successfully Treated by the Concomitant Use of Hydroxychloroquine and Corticosteroids
title Recurrent Kikuchi-Fujimoto Disease Successfully Treated by the Concomitant Use of Hydroxychloroquine and Corticosteroids
title_full Recurrent Kikuchi-Fujimoto Disease Successfully Treated by the Concomitant Use of Hydroxychloroquine and Corticosteroids
title_fullStr Recurrent Kikuchi-Fujimoto Disease Successfully Treated by the Concomitant Use of Hydroxychloroquine and Corticosteroids
title_full_unstemmed Recurrent Kikuchi-Fujimoto Disease Successfully Treated by the Concomitant Use of Hydroxychloroquine and Corticosteroids
title_short Recurrent Kikuchi-Fujimoto Disease Successfully Treated by the Concomitant Use of Hydroxychloroquine and Corticosteroids
title_sort recurrent kikuchi-fujimoto disease successfully treated by the concomitant use of hydroxychloroquine and corticosteroids
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790731/
https://www.ncbi.nlm.nih.gov/pubmed/29021444
http://dx.doi.org/10.2169/internalmedicine.9205-17
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