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Recurrent Kikuchi-Fujimoto Disease Successfully Treated by the Concomitant Use of Hydroxychloroquine and Corticosteroids
Kikuchi-Fujimoto disease (KFD) is a benign disease of unknown etiology characterized by lymphadenopathy and a fever. For the majority of patients with KFD, the course is self-limited; however, the optimum method of managing recurrent cases has not yet been established. We herein report a case of a 4...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Internal Medicine
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790731/ https://www.ncbi.nlm.nih.gov/pubmed/29021444 http://dx.doi.org/10.2169/internalmedicine.9205-17 |
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author | Honda, Fumika Tsuboi, Hiroto Toko, Hirofumi Ohyama, Ayako Takahashi, Hidenori Abe, Saori Yokosawa, Masahiro Asashima, Hiromitsu Hagiwara, Shinya Hirota, Tomoya Kondo, Yuya Matsumoto, Isao Sumida, Takayuki |
author_facet | Honda, Fumika Tsuboi, Hiroto Toko, Hirofumi Ohyama, Ayako Takahashi, Hidenori Abe, Saori Yokosawa, Masahiro Asashima, Hiromitsu Hagiwara, Shinya Hirota, Tomoya Kondo, Yuya Matsumoto, Isao Sumida, Takayuki |
author_sort | Honda, Fumika |
collection | PubMed |
description | Kikuchi-Fujimoto disease (KFD) is a benign disease of unknown etiology characterized by lymphadenopathy and a fever. For the majority of patients with KFD, the course is self-limited; however, the optimum method of managing recurrent cases has not yet been established. We herein report a case of a 42-year-old Japanese woman with KFD (confirmed by a lymph node biopsy). Although high-dose prednisolone (PSL) rapidly induced remission, she experienced four recurrences on treatment tapering. Concomitant use of hydroxychloroquine (HCQ) with low-dose PSL induced continuous remission. This is the first case to suggest the effectiveness of HCQ for recurrent KFD in a Japanese patient. |
format | Online Article Text |
id | pubmed-5790731 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | The Japanese Society of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-57907312018-01-31 Recurrent Kikuchi-Fujimoto Disease Successfully Treated by the Concomitant Use of Hydroxychloroquine and Corticosteroids Honda, Fumika Tsuboi, Hiroto Toko, Hirofumi Ohyama, Ayako Takahashi, Hidenori Abe, Saori Yokosawa, Masahiro Asashima, Hiromitsu Hagiwara, Shinya Hirota, Tomoya Kondo, Yuya Matsumoto, Isao Sumida, Takayuki Intern Med Case Report Kikuchi-Fujimoto disease (KFD) is a benign disease of unknown etiology characterized by lymphadenopathy and a fever. For the majority of patients with KFD, the course is self-limited; however, the optimum method of managing recurrent cases has not yet been established. We herein report a case of a 42-year-old Japanese woman with KFD (confirmed by a lymph node biopsy). Although high-dose prednisolone (PSL) rapidly induced remission, she experienced four recurrences on treatment tapering. Concomitant use of hydroxychloroquine (HCQ) with low-dose PSL induced continuous remission. This is the first case to suggest the effectiveness of HCQ for recurrent KFD in a Japanese patient. The Japanese Society of Internal Medicine 2017-10-11 2017-12-15 /pmc/articles/PMC5790731/ /pubmed/29021444 http://dx.doi.org/10.2169/internalmedicine.9205-17 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Honda, Fumika Tsuboi, Hiroto Toko, Hirofumi Ohyama, Ayako Takahashi, Hidenori Abe, Saori Yokosawa, Masahiro Asashima, Hiromitsu Hagiwara, Shinya Hirota, Tomoya Kondo, Yuya Matsumoto, Isao Sumida, Takayuki Recurrent Kikuchi-Fujimoto Disease Successfully Treated by the Concomitant Use of Hydroxychloroquine and Corticosteroids |
title | Recurrent Kikuchi-Fujimoto Disease Successfully Treated by the Concomitant Use of Hydroxychloroquine and Corticosteroids |
title_full | Recurrent Kikuchi-Fujimoto Disease Successfully Treated by the Concomitant Use of Hydroxychloroquine and Corticosteroids |
title_fullStr | Recurrent Kikuchi-Fujimoto Disease Successfully Treated by the Concomitant Use of Hydroxychloroquine and Corticosteroids |
title_full_unstemmed | Recurrent Kikuchi-Fujimoto Disease Successfully Treated by the Concomitant Use of Hydroxychloroquine and Corticosteroids |
title_short | Recurrent Kikuchi-Fujimoto Disease Successfully Treated by the Concomitant Use of Hydroxychloroquine and Corticosteroids |
title_sort | recurrent kikuchi-fujimoto disease successfully treated by the concomitant use of hydroxychloroquine and corticosteroids |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790731/ https://www.ncbi.nlm.nih.gov/pubmed/29021444 http://dx.doi.org/10.2169/internalmedicine.9205-17 |
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