Cargando…

The importance of early detection of calcifications associated with breast cancer in screening

PURPOSE: The aim of this study was to assess how often women with undetected calcifications in prior screening mammograms are subsequently diagnosed with invasive cancer. METHODS: From a screening cohort of 63,895 women, exams were collected from 59,690 women without any abnormalities, 744 women wit...

Descripción completa

Detalles Bibliográficos
Autores principales: Mordang, J. J., Gubern-Mérida, A., Bria, A., Tortorella, F., Mann, R. M., Broeders, M. J. M., den Heeten, G. J., Karssemeijer, N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790861/
https://www.ncbi.nlm.nih.gov/pubmed/29043464
http://dx.doi.org/10.1007/s10549-017-4527-7
_version_ 1783296525602914304
author Mordang, J. J.
Gubern-Mérida, A.
Bria, A.
Tortorella, F.
Mann, R. M.
Broeders, M. J. M.
den Heeten, G. J.
Karssemeijer, N.
author_facet Mordang, J. J.
Gubern-Mérida, A.
Bria, A.
Tortorella, F.
Mann, R. M.
Broeders, M. J. M.
den Heeten, G. J.
Karssemeijer, N.
author_sort Mordang, J. J.
collection PubMed
description PURPOSE: The aim of this study was to assess how often women with undetected calcifications in prior screening mammograms are subsequently diagnosed with invasive cancer. METHODS: From a screening cohort of 63,895 women, exams were collected from 59,690 women without any abnormalities, 744 women with a screen-detected cancer and a prior negative exam, 781 women with a false positive exam based on calcifications, and 413 women with an interval cancer. A radiologist identified cancer-related calcifications, selected by a computer-aided detection system, on mammograms taken prior to screen-detected or interval cancer diagnoses. Using this ground truth and the pathology reports, the sensitivity for calcification detection and the proportion of lesions with visible calcifications that developed into invasive cancer were determined. RESULTS: The screening sensitivity for calcifications was 45.5%, at a specificity of 99.5%. A total of 68.4% (n = 177) of cancer-related calcifications that could have been detected earlier were associated with invasive cancer when diagnosed. CONCLUSIONS: Screening sensitivity for detection of malignant calcifications is low. Improving the detection of these early signs of cancer is important, because the majority of lesions with detectable calcifications that are not recalled immediately but detected as interval cancer or in the next screening round are invasive at the time of diagnosis.
format Online
Article
Text
id pubmed-5790861
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-57908612018-02-05 The importance of early detection of calcifications associated with breast cancer in screening Mordang, J. J. Gubern-Mérida, A. Bria, A. Tortorella, F. Mann, R. M. Broeders, M. J. M. den Heeten, G. J. Karssemeijer, N. Breast Cancer Res Treat Preclinical Study PURPOSE: The aim of this study was to assess how often women with undetected calcifications in prior screening mammograms are subsequently diagnosed with invasive cancer. METHODS: From a screening cohort of 63,895 women, exams were collected from 59,690 women without any abnormalities, 744 women with a screen-detected cancer and a prior negative exam, 781 women with a false positive exam based on calcifications, and 413 women with an interval cancer. A radiologist identified cancer-related calcifications, selected by a computer-aided detection system, on mammograms taken prior to screen-detected or interval cancer diagnoses. Using this ground truth and the pathology reports, the sensitivity for calcification detection and the proportion of lesions with visible calcifications that developed into invasive cancer were determined. RESULTS: The screening sensitivity for calcifications was 45.5%, at a specificity of 99.5%. A total of 68.4% (n = 177) of cancer-related calcifications that could have been detected earlier were associated with invasive cancer when diagnosed. CONCLUSIONS: Screening sensitivity for detection of malignant calcifications is low. Improving the detection of these early signs of cancer is important, because the majority of lesions with detectable calcifications that are not recalled immediately but detected as interval cancer or in the next screening round are invasive at the time of diagnosis. Springer US 2017-10-17 2018 /pmc/articles/PMC5790861/ /pubmed/29043464 http://dx.doi.org/10.1007/s10549-017-4527-7 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Preclinical Study
Mordang, J. J.
Gubern-Mérida, A.
Bria, A.
Tortorella, F.
Mann, R. M.
Broeders, M. J. M.
den Heeten, G. J.
Karssemeijer, N.
The importance of early detection of calcifications associated with breast cancer in screening
title The importance of early detection of calcifications associated with breast cancer in screening
title_full The importance of early detection of calcifications associated with breast cancer in screening
title_fullStr The importance of early detection of calcifications associated with breast cancer in screening
title_full_unstemmed The importance of early detection of calcifications associated with breast cancer in screening
title_short The importance of early detection of calcifications associated with breast cancer in screening
title_sort importance of early detection of calcifications associated with breast cancer in screening
topic Preclinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790861/
https://www.ncbi.nlm.nih.gov/pubmed/29043464
http://dx.doi.org/10.1007/s10549-017-4527-7
work_keys_str_mv AT mordangjj theimportanceofearlydetectionofcalcificationsassociatedwithbreastcancerinscreening
AT gubernmeridaa theimportanceofearlydetectionofcalcificationsassociatedwithbreastcancerinscreening
AT briaa theimportanceofearlydetectionofcalcificationsassociatedwithbreastcancerinscreening
AT tortorellaf theimportanceofearlydetectionofcalcificationsassociatedwithbreastcancerinscreening
AT mannrm theimportanceofearlydetectionofcalcificationsassociatedwithbreastcancerinscreening
AT broedersmjm theimportanceofearlydetectionofcalcificationsassociatedwithbreastcancerinscreening
AT denheetengj theimportanceofearlydetectionofcalcificationsassociatedwithbreastcancerinscreening
AT karssemeijern theimportanceofearlydetectionofcalcificationsassociatedwithbreastcancerinscreening
AT mordangjj importanceofearlydetectionofcalcificationsassociatedwithbreastcancerinscreening
AT gubernmeridaa importanceofearlydetectionofcalcificationsassociatedwithbreastcancerinscreening
AT briaa importanceofearlydetectionofcalcificationsassociatedwithbreastcancerinscreening
AT tortorellaf importanceofearlydetectionofcalcificationsassociatedwithbreastcancerinscreening
AT mannrm importanceofearlydetectionofcalcificationsassociatedwithbreastcancerinscreening
AT broedersmjm importanceofearlydetectionofcalcificationsassociatedwithbreastcancerinscreening
AT denheetengj importanceofearlydetectionofcalcificationsassociatedwithbreastcancerinscreening
AT karssemeijern importanceofearlydetectionofcalcificationsassociatedwithbreastcancerinscreening