Cargando…

Translation Stress Positively Regulates MscL-Dependent Excretion of Cytoplasmic Proteins

The apparent mislocalization or excretion of cytoplasmic proteins is a commonly observed phenomenon in both bacteria and eukaryotes. However, reports on the mechanistic basis and the cellular function of this so-called “nonclassical protein secretion” are limited. Here we report that protein overexp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Morra, Rosa, Del Carratore, Francesco, Muhamadali, Howbeer, Horga, Luminita Gabriela, Halliwell, Samantha, Goodacre, Royston, Breitling, Rainer, Dixon, Neil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790912/ https://www.ncbi.nlm.nih.gov/pubmed/29382730 http://dx.doi.org/10.1128/mBio.02118-17

Ejemplares similares

arfA antisense RNA regulates MscL excretory activity
por: Morra, Rosa, et al.
Publicado: (2023)

Partial Least Squares with Structured Output for Modelling the Metabolomics Data Obtained from Complex Experimental Designs: A Study into the Y-Block Coding
por: Xu, Yun, et al.
Publicado: (2016)

Simultaneous Raman and Infrared Spectroscopy of Stable Isotope Labelled Escherichia coli
por: Lima, Cassio, et al.
Publicado: (2022)

Binding of fullerenes and nanotubes to MscL
por: Hilder, Tamsyn A., et al.
Publicado: (2014)

Scanning MscL Channels with Targeted Post-Translational Modifications for Functional Alterations
por: Iscla, Irene, et al.
Publicado: (2015)

Unlocking the secrets of the microbiome: exploring the dynamic microbial interplay with humans through metabolomics and their manipulation for synthetic biology applications
por: Muhamadali, Howbeer, et al.
Publicado: (2023)

Streptomycin potency is dependent on MscL channel expression
por: Iscla, Irene, et al.
Publicado: (2014)

Structural Dynamics of the MscL C-terminal Domain
por: Bavi, Navid, et al.
Publicado: (2017)

Approaches for the modulation of mechanosensitive MscL channel pores
por: Lane, Benjamin J., et al.
Publicado: (2023)

Pulling MscL open via N-terminal and TM1 helices: A computational study towards engineering an MscL nanovalve
por: Martinac, Adam D., et al.
Publicado: (2017)

Metabolic Fingerprint Analysis of Cytochrome b(5)-producing E. coli N4830-1 Using FT-IR Spectroscopy
por: Tengsuttiwat, Thanyaporn, et al.
Publicado: (2022)

Structure of a tetrameric MscL in an expanded intermediate state
por: Liu, Zhenfeng, et al.
Publicado: (2009)

Improving the Design of a MscL-Based Triggered Nanovalve
por: Iscla, Irene, et al.
Publicado: (2013)

A new antibiotic with potent activity targets MscL
por: Iscla, Irene, et al.
Publicado: (2015)

Study of light-induced MscL gating by EPR spectroscopy
por: Yilmaz, Duygu, et al.
Publicado: (2015)

Evaluation of Sample Preparation Methods for Inter-Laboratory Metabolomics Investigation of Streptomyces lividans TK24
por: Muhamadali, Howbeer, et al.
Publicado: (2020)

Optical photothermal infrared spectroscopy: A novel solution for rapid identification of antimicrobial resistance at the single-cell level via deuterium isotope labeling
por: Shams, Sahand, et al.
Publicado: (2023)

On the Conformation of the COOH-terminal Domain of the Large Mechanosensitive Channel MscL
por: Anishkin, Andriy, et al.
Publicado: (2003)

Novel MscL agonists that allow multiple antibiotics cytoplasmic access activate the channel through a common binding site
por: Wray, Robin, et al.
Publicado: (2020)

Activation of bacterial channel MscL in mechanically stimulated droplet interface bilayers
por: Najem, Joseph S., et al.
Publicado: (2015)

Force Transduction and Lipid Binding in MscL: A Continuum-Molecular Approach
por: Vanegas, Juan M., et al.
Publicado: (2014)

Dihydrostreptomycin Directly Binds to, Modulates, and Passes through the MscL Channel Pore
por: Wray, Robin, et al.
Publicado: (2016)

Energetic and Spatial Parameters for Gating of the Bacterial Large Conductance Mechanosensitive Channel, MscL
por: Sukharev, Sergei I., et al.
Publicado: (1999)

Breaking the Hydrophobicity of the MscL Pore: Insights into a Charge-Induced Gating Mechanism
por: Chandramouli, Balasubramanian, et al.
Publicado: (2015)

High-Throughput Simulations Reveal Membrane-Mediated Effects of Alcohols on MscL Gating
por: Melo, Manuel N., et al.
Publicado: (2017)

Through-container, extremely low concentration detection of multiple chemical markers of counterfeit alcohol using a handheld SORS device
por: Ellis, David I., et al.
Publicado: (2017)

An improved open-channel structure of MscL determined from FRET confocal microscopy and simulation
por: Corry, Ben, et al.
Publicado: (2010)

Structural Investigation of MscL Gating Using Experimental Data and Coarse Grained MD Simulations
por: Deplazes, Evelyne, et al.
Publicado: (2012)

Controlled delivery of bioactive molecules into live cells using the bacterial mechanosensitive channel MscL
por: Doerner, Julia F., et al.
Publicado: (2012)

Molecular dynamics study on protein–water interplay in the mechanogating of the bacterial mechanosensitive channel MscL
por: Sawada, Yasuyuki, et al.
Publicado: (2015)

The effect of mechanosensitive channel MscL expression in cancer cells on 3D confined migration
por: Heureaux-Torres, Johanna, et al.
Publicado: (2018)

Activation of the mechanosensitive ion channel MscL by mechanical stimulation of supported Droplet-Hydrogel bilayers
por: Rosholm, Kadla R., et al.
Publicado: (2017)

In Silico Screen Identifies a New Family of Agonists for the Bacterial Mechanosensitive Channel MscL
por: Wray, Robin, et al.
Publicado: (2022)

Metabolomics investigation of recombinant mTNFα production in Streptomyces lividans
por: Muhamadali, Howbeer, et al.
Publicado: (2015)

A microbiome and metabolomic signature of phases of cutaneous healing identified by profiling sequential acute wounds of human skin: An exploratory study
por: Ashrafi, Mohammed, et al.
Publicado: (2020)

Radiation Tolerance of Pseudanabaena catenata, a Cyanobacterium Relevant to the First Generation Magnox Storage Pond
por: Foster, Lynn, et al.
Publicado: (2020)

Simultaneous Raman and infrared spectroscopy: a novel combination for studying bacterial infections at the single cell level
por: Lima, Cassio, et al.
Publicado: (2022)

The voltage-dependence of MscL has dipolar and dielectric contributions and is governed by local intramembrane electric field
por: Najem, Joseph S., et al.
Publicado: (2018)

Rapid Detection and Quantification of Novel Psychoactive Substances (NPS) Using Raman Spectroscopy and Surface-Enhanced Raman Scattering
por: Muhamadali, Howbeer, et al.
Publicado: (2019)

Gain-of-function Mutations Reveal Expanded Intermediate States and a Sequential Action of Two Gates in MscL
por: Anishkin, Andriy, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_i6q2aqmm8imi4l81rjidt7hfg7