Microbial Unmasking of Plant Glycosides

The therapeutic potential of plants is widely recognized and harnessed in plant-based remedies and drug discovery. However, the factors that modulate the bioavailability and bioactivities of plant-derived phytochemicals are poorly understood. In a recent article in mBio, M. C. Theilmann et al. (mBio...

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Detalles Bibliográficos
Autores principales: Biernat, Kristen A., Li, Bo, Redinbo, Matthew R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790921/
https://www.ncbi.nlm.nih.gov/pubmed/29382739
http://dx.doi.org/10.1128/mBio.02433-17
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author Biernat, Kristen A.
Li, Bo
Redinbo, Matthew R.
author_facet Biernat, Kristen A.
Li, Bo
Redinbo, Matthew R.
author_sort Biernat, Kristen A.
collection PubMed
description The therapeutic potential of plants is widely recognized and harnessed in plant-based remedies and drug discovery. However, the factors that modulate the bioavailability and bioactivities of plant-derived phytochemicals are poorly understood. In a recent article in mBio, M. C. Theilmann et al. (mBio 8:e01421-17, 2017, https://doi.org/10.1128/mBio.01421-17) describe how one gut microbe, Lactobacillus acidophilus, catalytically unwraps plant glucosides to make deglucosylated bioactive aglycones available to human tissues. They demonstrate that understanding the metabolism of plant glycosides by intestinal bacteria is essential to appreciating how bacteria manipulate the levels of bioactive plant metabolites in the human host.
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spelling pubmed-57909212018-02-05 Microbial Unmasking of Plant Glycosides Biernat, Kristen A. Li, Bo Redinbo, Matthew R. mBio Commentary The therapeutic potential of plants is widely recognized and harnessed in plant-based remedies and drug discovery. However, the factors that modulate the bioavailability and bioactivities of plant-derived phytochemicals are poorly understood. In a recent article in mBio, M. C. Theilmann et al. (mBio 8:e01421-17, 2017, https://doi.org/10.1128/mBio.01421-17) describe how one gut microbe, Lactobacillus acidophilus, catalytically unwraps plant glucosides to make deglucosylated bioactive aglycones available to human tissues. They demonstrate that understanding the metabolism of plant glycosides by intestinal bacteria is essential to appreciating how bacteria manipulate the levels of bioactive plant metabolites in the human host. American Society for Microbiology 2018-01-30 /pmc/articles/PMC5790921/ /pubmed/29382739 http://dx.doi.org/10.1128/mBio.02433-17 Text en Copyright © 2018 Biernat et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Commentary
Biernat, Kristen A.
Li, Bo
Redinbo, Matthew R.
Microbial Unmasking of Plant Glycosides
title Microbial Unmasking of Plant Glycosides
title_full Microbial Unmasking of Plant Glycosides
title_fullStr Microbial Unmasking of Plant Glycosides
title_full_unstemmed Microbial Unmasking of Plant Glycosides
title_short Microbial Unmasking of Plant Glycosides
title_sort microbial unmasking of plant glycosides
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790921/
https://www.ncbi.nlm.nih.gov/pubmed/29382739
http://dx.doi.org/10.1128/mBio.02433-17
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