Keikipukalides, Furanocembrane Diterpenes from the Antarctic Deep Sea Octocoral Plumarella delicatissima

[Image: see text] During a 2013 cruise in the Southern Ocean we collected specimens of the octocoral Plumarella delicatissima between 800 and 950 m depth. Five new furanocembranoid diterpenes, keikipukalides A–E (1–5), the known diterpene pukalide aldehyde (6), and the known norditerpenoid inelegano...

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Autores principales: Thomas, Santana A. L., von Salm, Jacqueline L., Clark, Shane, Ferlita, Steve, Nemani, Prasanth, Azhari, Ala, Rice, Christopher A., Wilson, Nerida G., Kyle, Dennis E., Baker, Bill J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society and American Society of Pharmacognosy 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791048/
https://www.ncbi.nlm.nih.gov/pubmed/29260557
http://dx.doi.org/10.1021/acs.jnatprod.7b00732
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author Thomas, Santana A. L.
von Salm, Jacqueline L.
Clark, Shane
Ferlita, Steve
Nemani, Prasanth
Azhari, Ala
Rice, Christopher A.
Wilson, Nerida G.
Kyle, Dennis E.
Baker, Bill J.
author_facet Thomas, Santana A. L.
von Salm, Jacqueline L.
Clark, Shane
Ferlita, Steve
Nemani, Prasanth
Azhari, Ala
Rice, Christopher A.
Wilson, Nerida G.
Kyle, Dennis E.
Baker, Bill J.
author_sort Thomas, Santana A. L.
collection PubMed
description [Image: see text] During a 2013 cruise in the Southern Ocean we collected specimens of the octocoral Plumarella delicatissima between 800 and 950 m depth. Five new furanocembranoid diterpenes, keikipukalides A–E (1–5), the known diterpene pukalide aldehyde (6), and the known norditerpenoid ineleganolide (7) were isolated from the coral. These Plumarella terpenes lack mammalian cytotoxicity, while 2–7 display activity against Leishmania donovani between 1.9 and 12 μM. Structure elucidation was facilitated by one- and two-dimensional NMR spectroscopy and mass spectrometry, and keikipukalides A and E were confirmed by X-ray crystallography.
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spelling pubmed-57910482018-02-01 Keikipukalides, Furanocembrane Diterpenes from the Antarctic Deep Sea Octocoral Plumarella delicatissima Thomas, Santana A. L. von Salm, Jacqueline L. Clark, Shane Ferlita, Steve Nemani, Prasanth Azhari, Ala Rice, Christopher A. Wilson, Nerida G. Kyle, Dennis E. Baker, Bill J. J Nat Prod [Image: see text] During a 2013 cruise in the Southern Ocean we collected specimens of the octocoral Plumarella delicatissima between 800 and 950 m depth. Five new furanocembranoid diterpenes, keikipukalides A–E (1–5), the known diterpene pukalide aldehyde (6), and the known norditerpenoid ineleganolide (7) were isolated from the coral. These Plumarella terpenes lack mammalian cytotoxicity, while 2–7 display activity against Leishmania donovani between 1.9 and 12 μM. Structure elucidation was facilitated by one- and two-dimensional NMR spectroscopy and mass spectrometry, and keikipukalides A and E were confirmed by X-ray crystallography. American Chemical Society and American Society of Pharmacognosy 2017-12-20 2018-01-26 /pmc/articles/PMC5791048/ /pubmed/29260557 http://dx.doi.org/10.1021/acs.jnatprod.7b00732 Text en Copyright © 2017 American Chemical Society and American Society of Pharmacognosy This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Thomas, Santana A. L.
von Salm, Jacqueline L.
Clark, Shane
Ferlita, Steve
Nemani, Prasanth
Azhari, Ala
Rice, Christopher A.
Wilson, Nerida G.
Kyle, Dennis E.
Baker, Bill J.
Keikipukalides, Furanocembrane Diterpenes from the Antarctic Deep Sea Octocoral Plumarella delicatissima
title Keikipukalides, Furanocembrane Diterpenes from the Antarctic Deep Sea Octocoral Plumarella delicatissima
title_full Keikipukalides, Furanocembrane Diterpenes from the Antarctic Deep Sea Octocoral Plumarella delicatissima
title_fullStr Keikipukalides, Furanocembrane Diterpenes from the Antarctic Deep Sea Octocoral Plumarella delicatissima
title_full_unstemmed Keikipukalides, Furanocembrane Diterpenes from the Antarctic Deep Sea Octocoral Plumarella delicatissima
title_short Keikipukalides, Furanocembrane Diterpenes from the Antarctic Deep Sea Octocoral Plumarella delicatissima
title_sort keikipukalides, furanocembrane diterpenes from the antarctic deep sea octocoral plumarella delicatissima
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791048/
https://www.ncbi.nlm.nih.gov/pubmed/29260557
http://dx.doi.org/10.1021/acs.jnatprod.7b00732
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