Different TP53 mutants in p53 overexpressed epithelial ovarian carcinoma can be associated both with altered and unaltered glycolytic and apoptotic profiles

BACKGROUND: p53 is a tumor suppressor and key regulator of glycolysis in cancer cells, however highly mutated in tumors. In ovarian cancer, studies concerning p53 mutations focus on the DNA binding domain since the majority of hotspot mutations affects this region. Yet, mutations in other regions su...

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Detalles Bibliográficos
Autores principales: Antoun, Stephanie, Atallah, David, Tahtouh, Roula, Alaaeddine, Nada, Moubarak, Malak, Khaddage, Abir, Ayoub, Eliane Nasr, Chahine, George, Hilal, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791177/
https://www.ncbi.nlm.nih.gov/pubmed/29422776
http://dx.doi.org/10.1186/s12935-018-0514-2

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