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Systemic arteriosclerosis is associated with left ventricular remodeling but not atherosclerosis: a TASCFORCE study

BACKGROUND: Arteriosclerosis (arterial stiffening) is associated with future cardiovascular events, with this effect postulated to be due to its effect on cardiac afterload, atherosclerosis (plaque formation) progression or both, but with limited evidence examining these early in disease formation....

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Autores principales: Weir-McCall, Jonathan R., Lambert, Matthew, Gandy, Stephen J., Belch, Jill J. F., Cavin, Ian, Henderson, Shelley A., Littleford, Roberta, Macfarlane, Jennifer A., Matthew, Shona Z., Stephen Nicholas, R., Struthers, Allan D., Sullivan, Frank, White, Richard D., Graeme Houston, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791244/
https://www.ncbi.nlm.nih.gov/pubmed/29382349
http://dx.doi.org/10.1186/s12968-018-0428-0
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author Weir-McCall, Jonathan R.
Lambert, Matthew
Gandy, Stephen J.
Belch, Jill J. F.
Cavin, Ian
Henderson, Shelley A.
Littleford, Roberta
Macfarlane, Jennifer A.
Matthew, Shona Z.
Stephen Nicholas, R.
Struthers, Allan D.
Sullivan, Frank
White, Richard D.
Graeme Houston, J.
author_facet Weir-McCall, Jonathan R.
Lambert, Matthew
Gandy, Stephen J.
Belch, Jill J. F.
Cavin, Ian
Henderson, Shelley A.
Littleford, Roberta
Macfarlane, Jennifer A.
Matthew, Shona Z.
Stephen Nicholas, R.
Struthers, Allan D.
Sullivan, Frank
White, Richard D.
Graeme Houston, J.
author_sort Weir-McCall, Jonathan R.
collection PubMed
description BACKGROUND: Arteriosclerosis (arterial stiffening) is associated with future cardiovascular events, with this effect postulated to be due to its effect on cardiac afterload, atherosclerosis (plaque formation) progression or both, but with limited evidence examining these early in disease formation. The aim of the current study is to examine the association between arteriosclerosis, atherosclerosis and ventricular remodelling in a population at low-intermediate cardiovascular risk. METHODS: One thousand six hundred fifty-one subjects free of clinical cardiovascular disease and with a < 20% 10 year cardiovascular risk score underwent a cardiovascular magnetic resonance (CMR) study and whole body CMR angiogram. Arteriosclerosis was measured using total arterial compliance (TAC) - calculated as the indexed stroke volume divided by the pulse pressure. Atherosclerosis was quantified using a standardised atheroma score (SAS) which was calculated by scoring 30 arterial segments within the body based on the degree of stenosis, summating these scores and normalising it to the number of assessable segments. Left ventricular remodelling was measured using left ventricular mass to volume ratio (LVMVR). RESULTS: One thousand five hundred fifteen (38% male, 53.8 ± 8.2 years old) completed the study. On univariate analysis TAC was associated with SAS but this was lost after accounting for cardiovascular risk factors in both males (B = − 0.001 (− 0.004–0.002),p = 0.62) and females (B = 0.000(95%CI -0.002--0.002),p = 0.78). In contrast compliance correlated with LVMVR after accounting for cardiovascular risk factors (B = − 0.12(95%CI -0.16--0.091),p < 0.001 in males; B = − 0.12(95%CI -0.15--0.086),p < 0.001 in females). CONCLUSION: Systemic arteriosclerosis is associated with left ventricular remodelling but not atherosclerosis. Future efforts in cardiovascular risk prevention should thus seek to address both arteriosclerosis and atherosclerosis individually. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12968-018-0428-0) contains supplementary material, which is available to authorized users.
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spelling pubmed-57912442018-02-08 Systemic arteriosclerosis is associated with left ventricular remodeling but not atherosclerosis: a TASCFORCE study Weir-McCall, Jonathan R. Lambert, Matthew Gandy, Stephen J. Belch, Jill J. F. Cavin, Ian Henderson, Shelley A. Littleford, Roberta Macfarlane, Jennifer A. Matthew, Shona Z. Stephen Nicholas, R. Struthers, Allan D. Sullivan, Frank White, Richard D. Graeme Houston, J. J Cardiovasc Magn Reson Research BACKGROUND: Arteriosclerosis (arterial stiffening) is associated with future cardiovascular events, with this effect postulated to be due to its effect on cardiac afterload, atherosclerosis (plaque formation) progression or both, but with limited evidence examining these early in disease formation. The aim of the current study is to examine the association between arteriosclerosis, atherosclerosis and ventricular remodelling in a population at low-intermediate cardiovascular risk. METHODS: One thousand six hundred fifty-one subjects free of clinical cardiovascular disease and with a < 20% 10 year cardiovascular risk score underwent a cardiovascular magnetic resonance (CMR) study and whole body CMR angiogram. Arteriosclerosis was measured using total arterial compliance (TAC) - calculated as the indexed stroke volume divided by the pulse pressure. Atherosclerosis was quantified using a standardised atheroma score (SAS) which was calculated by scoring 30 arterial segments within the body based on the degree of stenosis, summating these scores and normalising it to the number of assessable segments. Left ventricular remodelling was measured using left ventricular mass to volume ratio (LVMVR). RESULTS: One thousand five hundred fifteen (38% male, 53.8 ± 8.2 years old) completed the study. On univariate analysis TAC was associated with SAS but this was lost after accounting for cardiovascular risk factors in both males (B = − 0.001 (− 0.004–0.002),p = 0.62) and females (B = 0.000(95%CI -0.002--0.002),p = 0.78). In contrast compliance correlated with LVMVR after accounting for cardiovascular risk factors (B = − 0.12(95%CI -0.16--0.091),p < 0.001 in males; B = − 0.12(95%CI -0.15--0.086),p < 0.001 in females). CONCLUSION: Systemic arteriosclerosis is associated with left ventricular remodelling but not atherosclerosis. Future efforts in cardiovascular risk prevention should thus seek to address both arteriosclerosis and atherosclerosis individually. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12968-018-0428-0) contains supplementary material, which is available to authorized users. BioMed Central 2018-01-30 /pmc/articles/PMC5791244/ /pubmed/29382349 http://dx.doi.org/10.1186/s12968-018-0428-0 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Weir-McCall, Jonathan R.
Lambert, Matthew
Gandy, Stephen J.
Belch, Jill J. F.
Cavin, Ian
Henderson, Shelley A.
Littleford, Roberta
Macfarlane, Jennifer A.
Matthew, Shona Z.
Stephen Nicholas, R.
Struthers, Allan D.
Sullivan, Frank
White, Richard D.
Graeme Houston, J.
Systemic arteriosclerosis is associated with left ventricular remodeling but not atherosclerosis: a TASCFORCE study
title Systemic arteriosclerosis is associated with left ventricular remodeling but not atherosclerosis: a TASCFORCE study
title_full Systemic arteriosclerosis is associated with left ventricular remodeling but not atherosclerosis: a TASCFORCE study
title_fullStr Systemic arteriosclerosis is associated with left ventricular remodeling but not atherosclerosis: a TASCFORCE study
title_full_unstemmed Systemic arteriosclerosis is associated with left ventricular remodeling but not atherosclerosis: a TASCFORCE study
title_short Systemic arteriosclerosis is associated with left ventricular remodeling but not atherosclerosis: a TASCFORCE study
title_sort systemic arteriosclerosis is associated with left ventricular remodeling but not atherosclerosis: a tascforce study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791244/
https://www.ncbi.nlm.nih.gov/pubmed/29382349
http://dx.doi.org/10.1186/s12968-018-0428-0
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