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Trend analysis of bacterial uropathogens and their susceptibility pattern: A 4-year (2013–2016) study from Aseer region, Saudi Arabia
PURPOSE: To analyze the prevalence and resistance rates of bacterial agents causing urinary tract infections (UTIs) in Aseer, Saudi Arabia (2013–2016). PATIENTS AND METHODS: This was a 4-year (2013–2016) retrospective study undertaken in Aseer Central Hospital, Saudi Arabia. A total of 49,779 urine...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791456/ https://www.ncbi.nlm.nih.gov/pubmed/29416274 http://dx.doi.org/10.4103/UA.UA_68_17 |
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author | Alamri, Abdulaziz Hamid, Mohamed E. Abid, Muhammad Alwahhabi, Abdulrahman M. Alqahtani, Khalid M. Alqarni, Mohammed S. Abomughaid, Mosleh |
author_facet | Alamri, Abdulaziz Hamid, Mohamed E. Abid, Muhammad Alwahhabi, Abdulrahman M. Alqahtani, Khalid M. Alqarni, Mohammed S. Abomughaid, Mosleh |
author_sort | Alamri, Abdulaziz |
collection | PubMed |
description | PURPOSE: To analyze the prevalence and resistance rates of bacterial agents causing urinary tract infections (UTIs) in Aseer, Saudi Arabia (2013–2016). PATIENTS AND METHODS: This was a 4-year (2013–2016) retrospective study undertaken in Aseer Central Hospital, Saudi Arabia. A total of 49,779 urine and other UT specimens obtained from patients suspected of having a UTI were analyzed. Urine specimens were inoculated onto cystine lactose electrolyte deficient agar following standard procedures. Cultures showing significant bacteriuria were subjected to identification and sensitivity testing using VITEK 2 system. Data of patients and uropathogens were assembled, checked, and analyzed using SPSS software. RESULTS: Culture positive samples were 49,779 (59.9% males, 40.1% females; P = 0.000). Year trend showed significant variations (P = 0.000) and the forecast trend line hypothesized a clear rise. Age groups 70–79 years were the most vulnerable group (22.3%). Gram-negative bacilli were 91.8% and the major species were Escherichia coli - 39.7%, Klebsiella pneumoniae - 15.8%; Pseudomonas aeruginosa - 13.8%, Proteus mirabilis - 10.6%, and Acinetobacter baumannii - 5%. Antimicrobials with high sensitivity rate were linezolid (99.1%), daptomycin (89.3%), vancomycin (86.7%), teicoplanin (85.5%), ertapenem (85.1%), fosfomycin (82.1%), and tigecycline (80.2%). High resistant rates to uropathogens were encountered with cephalothin (89.8%), nalidixic acid (86.7%), and ampicillin (81.9%). CONCLUSIONS: The majority of uropathogens were resistant to antibiotics commonly used in clinical practice. Linezolid, daptomycin, and vancomycin showed the lowest resistance to all uropathogens; this can be revised for empirical treatment of UTIs. Continuous surveillance of uropathogens and their susceptibility is important. |
format | Online Article Text |
id | pubmed-5791456 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-57914562018-02-07 Trend analysis of bacterial uropathogens and their susceptibility pattern: A 4-year (2013–2016) study from Aseer region, Saudi Arabia Alamri, Abdulaziz Hamid, Mohamed E. Abid, Muhammad Alwahhabi, Abdulrahman M. Alqahtani, Khalid M. Alqarni, Mohammed S. Abomughaid, Mosleh Urol Ann Original Article PURPOSE: To analyze the prevalence and resistance rates of bacterial agents causing urinary tract infections (UTIs) in Aseer, Saudi Arabia (2013–2016). PATIENTS AND METHODS: This was a 4-year (2013–2016) retrospective study undertaken in Aseer Central Hospital, Saudi Arabia. A total of 49,779 urine and other UT specimens obtained from patients suspected of having a UTI were analyzed. Urine specimens were inoculated onto cystine lactose electrolyte deficient agar following standard procedures. Cultures showing significant bacteriuria were subjected to identification and sensitivity testing using VITEK 2 system. Data of patients and uropathogens were assembled, checked, and analyzed using SPSS software. RESULTS: Culture positive samples were 49,779 (59.9% males, 40.1% females; P = 0.000). Year trend showed significant variations (P = 0.000) and the forecast trend line hypothesized a clear rise. Age groups 70–79 years were the most vulnerable group (22.3%). Gram-negative bacilli were 91.8% and the major species were Escherichia coli - 39.7%, Klebsiella pneumoniae - 15.8%; Pseudomonas aeruginosa - 13.8%, Proteus mirabilis - 10.6%, and Acinetobacter baumannii - 5%. Antimicrobials with high sensitivity rate were linezolid (99.1%), daptomycin (89.3%), vancomycin (86.7%), teicoplanin (85.5%), ertapenem (85.1%), fosfomycin (82.1%), and tigecycline (80.2%). High resistant rates to uropathogens were encountered with cephalothin (89.8%), nalidixic acid (86.7%), and ampicillin (81.9%). CONCLUSIONS: The majority of uropathogens were resistant to antibiotics commonly used in clinical practice. Linezolid, daptomycin, and vancomycin showed the lowest resistance to all uropathogens; this can be revised for empirical treatment of UTIs. Continuous surveillance of uropathogens and their susceptibility is important. Medknow Publications & Media Pvt Ltd 2018 /pmc/articles/PMC5791456/ /pubmed/29416274 http://dx.doi.org/10.4103/UA.UA_68_17 Text en Copyright: © 2018 Urology Annals http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Alamri, Abdulaziz Hamid, Mohamed E. Abid, Muhammad Alwahhabi, Abdulrahman M. Alqahtani, Khalid M. Alqarni, Mohammed S. Abomughaid, Mosleh Trend analysis of bacterial uropathogens and their susceptibility pattern: A 4-year (2013–2016) study from Aseer region, Saudi Arabia |
title | Trend analysis of bacterial uropathogens and their susceptibility pattern: A 4-year (2013–2016) study from Aseer region, Saudi Arabia |
title_full | Trend analysis of bacterial uropathogens and their susceptibility pattern: A 4-year (2013–2016) study from Aseer region, Saudi Arabia |
title_fullStr | Trend analysis of bacterial uropathogens and their susceptibility pattern: A 4-year (2013–2016) study from Aseer region, Saudi Arabia |
title_full_unstemmed | Trend analysis of bacterial uropathogens and their susceptibility pattern: A 4-year (2013–2016) study from Aseer region, Saudi Arabia |
title_short | Trend analysis of bacterial uropathogens and their susceptibility pattern: A 4-year (2013–2016) study from Aseer region, Saudi Arabia |
title_sort | trend analysis of bacterial uropathogens and their susceptibility pattern: a 4-year (2013–2016) study from aseer region, saudi arabia |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791456/ https://www.ncbi.nlm.nih.gov/pubmed/29416274 http://dx.doi.org/10.4103/UA.UA_68_17 |
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