Sequential administration of MVA-based vaccines and PD-1/PD-L1-blocking antibodies confers measurable benefits on tumor growth and survival: Preclinical studies with MVA-βGal and MVA-MUC1 (TG4010) in a murine tumor model

TG4010, a Modified Vaccinia virus Ankara (MVA) expressing human mucin1 (MUC1) has demonstrated clinical benefit for patients suffering from advanced non-small cell lung cancer (NSCLC) in combination with chemotherapy. To support its development, preclinical experiments were performed with either TG4...

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Detalles Bibliográficos
Autores principales: Remy-Ziller, Christelle, Thioudellet, Christine, Hortelano, Julie, Gantzer, Murielle, Nourtier, Virginie, Claudepierre, Marie-Christine, Sansas, Benoit, Préville, Xavier, Bendjama, Kaïdre, Quemeneur, Eric, Rittner, Karola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791558/
https://www.ncbi.nlm.nih.gov/pubmed/28925793
http://dx.doi.org/10.1080/21645515.2017.1373921

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