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Serum caffeine and metabolites are reliable biomarkers of early Parkinson disease

OBJECTIVE: To investigate the kinetics and metabolism of caffeine in serum from patients with Parkinson disease (PD) and controls using liquid chromatography–mass spectrometry. METHODS: Levels of caffeine and its 11 metabolites in serum from 108 patients with PD and 31 age-matched healthy controls w...

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Detalles Bibliográficos
Autores principales:	Fujimaki, Motoki, Saiki, Shinji, Li, Yuanzhe, Kaga, Naoko, Taka, Hikari, Hatano, Taku, Ishikawa, Kei-Ichi, Oji, Yutaka, Mori, Akio, Okuzumi, Ayami, Koinuma, Takahiro, Ueno, Shin-Ichi, Imamichi, Yoko, Ueno, Takashi, Miura, Yoshiki, Funayama, Manabu, Hattori, Nobutaka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791797/ https://www.ncbi.nlm.nih.gov/pubmed/29298852 http://dx.doi.org/10.1212/WNL.0000000000004888

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