New tricks for an old dog: Brf2-dependent RNA Polymerase III transcription in oxidative stress and cancer

Here, we discuss the role of Brf2, an RNA Polymerase III core transcription factor, as a master switch of the oxidative stress response. We highlight the interplay of Brf2 with the Nrf2/Keap1 pathway, as well as the role of Brf2 in cancer and other possible regulations.

Detalles Bibliográficos
Autores principales: Gouge, Jerome, Vannini, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Point-of-View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791813/
https://www.ncbi.nlm.nih.gov/pubmed/28854119
http://dx.doi.org/10.1080/21541264.2017.1335269
Descripción
Sumario:Here, we discuss the role of Brf2, an RNA Polymerase III core transcription factor, as a master switch of the oxidative stress response. We highlight the interplay of Brf2 with the Nrf2/Keap1 pathway, as well as the role of Brf2 in cancer and other possible regulations.

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