Hinge action versus grip in translocation by RNA polymerase

Based on molecular dynamics simulations and functional studies, a conformational mechanism is posited for forward translocation by RNA polymerase (RNAP). In a simulation of a ternary elongation complex, the clamp and downstream cleft were observed to close. Hinges within the bridge helix and trigger...

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Detalles Bibliográficos
Autores principales: Nedialkov, Yuri A., Opron, Kristopher, Caudill, Hailey L., Assaf, Fadi, Anderson, Amanda J., Cukier, Robert I., Wei, Guowei, Burton, Zachary F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791816/
https://www.ncbi.nlm.nih.gov/pubmed/28853995
http://dx.doi.org/10.1080/21541264.2017.1330179

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