COBRA methods and metabolic drug targets in cancer

The identification of therapeutic strategies exploiting the metabolic alterations of malignant cells is a relevant area in cancer research. Here, we discuss a novel computational method, based on the COBRA (COnstraint-Based Reconstruction and Analysis) framework for metabolic networks, to perform th...

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Autores principales: Apaolaza, Iñigo, José-Eneriz, Edurne San, Agirre, Xabier, Prósper, Felipe, Planes, Francisco J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791858/
https://www.ncbi.nlm.nih.gov/pubmed/29404389
http://dx.doi.org/10.1080/23723556.2017.1389672
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author Apaolaza, Iñigo
José-Eneriz, Edurne San
Agirre, Xabier
Prósper, Felipe
Planes, Francisco J.
author_facet Apaolaza, Iñigo
José-Eneriz, Edurne San
Agirre, Xabier
Prósper, Felipe
Planes, Francisco J.
author_sort Apaolaza, Iñigo
collection PubMed
description The identification of therapeutic strategies exploiting the metabolic alterations of malignant cells is a relevant area in cancer research. Here, we discuss a novel computational method, based on the COBRA (COnstraint-Based Reconstruction and Analysis) framework for metabolic networks, to perform this task. Current and future steps are presented.
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spelling pubmed-57918582018-11-30 COBRA methods and metabolic drug targets in cancer Apaolaza, Iñigo José-Eneriz, Edurne San Agirre, Xabier Prósper, Felipe Planes, Francisco J. Mol Cell Oncol Author's Views The identification of therapeutic strategies exploiting the metabolic alterations of malignant cells is a relevant area in cancer research. Here, we discuss a novel computational method, based on the COBRA (COnstraint-Based Reconstruction and Analysis) framework for metabolic networks, to perform this task. Current and future steps are presented. Taylor & Francis 2017-11-30 /pmc/articles/PMC5791858/ /pubmed/29404389 http://dx.doi.org/10.1080/23723556.2017.1389672 Text en © 2018 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
Apaolaza, Iñigo
José-Eneriz, Edurne San
Agirre, Xabier
Prósper, Felipe
Planes, Francisco J.
COBRA methods and metabolic drug targets in cancer
title COBRA methods and metabolic drug targets in cancer
title_full COBRA methods and metabolic drug targets in cancer
title_fullStr COBRA methods and metabolic drug targets in cancer
title_full_unstemmed COBRA methods and metabolic drug targets in cancer
title_short COBRA methods and metabolic drug targets in cancer
title_sort cobra methods and metabolic drug targets in cancer
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791858/
https://www.ncbi.nlm.nih.gov/pubmed/29404389
http://dx.doi.org/10.1080/23723556.2017.1389672
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AT agirrexabier cobramethodsandmetabolicdrugtargetsincancer
AT prosperfelipe cobramethodsandmetabolicdrugtargetsincancer
AT planesfranciscoj cobramethodsandmetabolicdrugtargetsincancer

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