Dimeric quinacrines as chemical tools to identify PPT1, a new regulator of autophagy in cancer cells

DQ661 is a novel dimeric quinacrine that affects multiple lysosomal functions (autophagy and macropinocytosis) and mTORC1 (mechanistic target of rapamycin) activity by specifically targeting protein-palmitoyl thioesterase 1 (PPT1). DQ661 has in vivo activity in immunocompetent mouse models of cancer...

Descripción completa

Detalles Bibliográficos
Autores principales: Nicastri, Michael C., Rebecca, Vito W., Amaravadi, Ravi K., Winkler, Jeffrey D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791860/
https://www.ncbi.nlm.nih.gov/pubmed/29404393
http://dx.doi.org/10.1080/23723556.2017.1395504
Descripción
Sumario:DQ661 is a novel dimeric quinacrine that affects multiple lysosomal functions (autophagy and macropinocytosis) and mTORC1 (mechanistic target of rapamycin) activity by specifically targeting protein-palmitoyl thioesterase 1 (PPT1). DQ661 has in vivo activity in immunocompetent mouse models of cancer, and constitutes a new tool compound for the study of lysosomal function in cancer and therapeutic resistance.

Ejemplares similares