Dimeric quinacrines as chemical tools to identify PPT1, a new regulator of autophagy in cancer cells

DQ661 is a novel dimeric quinacrine that affects multiple lysosomal functions (autophagy and macropinocytosis) and mTORC1 (mechanistic target of rapamycin) activity by specifically targeting protein-palmitoyl thioesterase 1 (PPT1). DQ661 has in vivo activity in immunocompetent mouse models of cancer...

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Autores principales: Nicastri, Michael C., Rebecca, Vito W., Amaravadi, Ravi K., Winkler, Jeffrey D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791860/
https://www.ncbi.nlm.nih.gov/pubmed/29404393
http://dx.doi.org/10.1080/23723556.2017.1395504
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author Nicastri, Michael C.
Rebecca, Vito W.
Amaravadi, Ravi K.
Winkler, Jeffrey D.
author_facet Nicastri, Michael C.
Rebecca, Vito W.
Amaravadi, Ravi K.
Winkler, Jeffrey D.
author_sort Nicastri, Michael C.
collection PubMed
description DQ661 is a novel dimeric quinacrine that affects multiple lysosomal functions (autophagy and macropinocytosis) and mTORC1 (mechanistic target of rapamycin) activity by specifically targeting protein-palmitoyl thioesterase 1 (PPT1). DQ661 has in vivo activity in immunocompetent mouse models of cancer, and constitutes a new tool compound for the study of lysosomal function in cancer and therapeutic resistance.
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spelling pubmed-57918602018-11-30 Dimeric quinacrines as chemical tools to identify PPT1, a new regulator of autophagy in cancer cells Nicastri, Michael C. Rebecca, Vito W. Amaravadi, Ravi K. Winkler, Jeffrey D. Mol Cell Oncol Author's Views DQ661 is a novel dimeric quinacrine that affects multiple lysosomal functions (autophagy and macropinocytosis) and mTORC1 (mechanistic target of rapamycin) activity by specifically targeting protein-palmitoyl thioesterase 1 (PPT1). DQ661 has in vivo activity in immunocompetent mouse models of cancer, and constitutes a new tool compound for the study of lysosomal function in cancer and therapeutic resistance. Taylor & Francis 2017-11-30 /pmc/articles/PMC5791860/ /pubmed/29404393 http://dx.doi.org/10.1080/23723556.2017.1395504 Text en © 2018 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
Nicastri, Michael C.
Rebecca, Vito W.
Amaravadi, Ravi K.
Winkler, Jeffrey D.
Dimeric quinacrines as chemical tools to identify PPT1, a new regulator of autophagy in cancer cells
title Dimeric quinacrines as chemical tools to identify PPT1, a new regulator of autophagy in cancer cells
title_full Dimeric quinacrines as chemical tools to identify PPT1, a new regulator of autophagy in cancer cells
title_fullStr Dimeric quinacrines as chemical tools to identify PPT1, a new regulator of autophagy in cancer cells
title_full_unstemmed Dimeric quinacrines as chemical tools to identify PPT1, a new regulator of autophagy in cancer cells
title_short Dimeric quinacrines as chemical tools to identify PPT1, a new regulator of autophagy in cancer cells
title_sort dimeric quinacrines as chemical tools to identify ppt1, a new regulator of autophagy in cancer cells
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791860/
https://www.ncbi.nlm.nih.gov/pubmed/29404393
http://dx.doi.org/10.1080/23723556.2017.1395504
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