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Dimeric quinacrines as chemical tools to identify PPT1, a new regulator of autophagy in cancer cells

DQ661 is a novel dimeric quinacrine that affects multiple lysosomal functions (autophagy and macropinocytosis) and mTORC1 (mechanistic target of rapamycin) activity by specifically targeting protein-palmitoyl thioesterase 1 (PPT1). DQ661 has in vivo activity in immunocompetent mouse models of cancer...

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Detalles Bibliográficos
Autores principales:	Nicastri, Michael C., Rebecca, Vito W., Amaravadi, Ravi K., Winkler, Jeffrey D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2017
Materias:	Author's Views
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791860/ https://www.ncbi.nlm.nih.gov/pubmed/29404393 http://dx.doi.org/10.1080/23723556.2017.1395504

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