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Preferential use of unmutated immunoglobulin heavy variable region genes in Boxer dogs with chronic lymphocytic leukemia

Human chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease, and immunoglobulin heavy variable region (IGHV) gene mutational status is an important prognostic marker. IGHV mutational status has not been previously examined in canine CLL. We sequenced the IGHV-D-J rearrangements fr...

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Detalles Bibliográficos
Autores principales:	Rout, Emily D., Burnett, Robert C., Labadie, Julia D., Yoshimoto, Janna A., Avery, Anne C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791963/ https://www.ncbi.nlm.nih.gov/pubmed/29385200 http://dx.doi.org/10.1371/journal.pone.0191205

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