Treatment with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice

BACKGROUND: Forty million adults in the US suffer from anxiety disorders, making these the most common forms of mental illness. Transient receptor potential channel canonical subfamily (TRPC) members 4 and 5 are non-selective cation channels highly expressed in regions of the cortex and amygdala, ar...

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Detalles Bibliográficos
Autores principales: Just, Stefan, Chenard, Bertrand L., Ceci, Angelo, Strassmaier, Timothy, Chong, Jayhong A., Blair, Nathaniel T., Gallaschun, Randall J., del Camino, Donato, Cantin, Susan, D’Amours, Marc, Eickmeier, Christian, Fanger, Christopher M., Hecker, Carsten, Hessler, David P., Hengerer, Bastian, Kroker, Katja S., Malekiani, Sam, Mihalek, Robert, McLaughlin, Joseph, Rast, Georg, Witek, JoAnn, Sauer, Achim, Pryce, Christopher R., Moran, Magdalene M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791972/
https://www.ncbi.nlm.nih.gov/pubmed/29385160
http://dx.doi.org/10.1371/journal.pone.0191225

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