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Association between meibomian gland dysfunction and compliance of topical prostaglandin analogs in patients with normal tension glaucoma
PURPOSE: The aim of this study was to investigate the association between tear film and meibomian gland parameters in patients with normal tension glaucoma (NTG), who underwent topical prostaglandin analog (PGA) monotherapy, and medication compliance. METHODS: Ocular surface disease index (OSDI), Sc...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791996/ https://www.ncbi.nlm.nih.gov/pubmed/29385185 http://dx.doi.org/10.1371/journal.pone.0191398 |
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author | Lee, Tae Hee Sung, Mi Sun Heo, Hwan Park, Sang Woo |
author_facet | Lee, Tae Hee Sung, Mi Sun Heo, Hwan Park, Sang Woo |
author_sort | Lee, Tae Hee |
collection | PubMed |
description | PURPOSE: The aim of this study was to investigate the association between tear film and meibomian gland parameters in patients with normal tension glaucoma (NTG), who underwent topical prostaglandin analog (PGA) monotherapy, and medication compliance. METHODS: Ocular surface disease index (OSDI), Schirmer’s test, tear film break-up time (TBUT), keratoepitheliopathy (KEP) score with fluorescein, and meibomian gland parameters were assessed in 45 eyes of 45 patients with NTG (NTG group), who received topical PGA monotherapy for more than 1 year. The results were compared to those of 40 eyes of 40 normal subjects (control group). Medication compliance was assessed by an 8-item Morisky Medication Adherence Scale (MMAS-8). Multiple logistic regression analysis was used to identify the factors associated with medication compliance. RESULTS: There was a significant difference in OSDI (P = 0.043), Schirmer’s test (P < 0.001), TBUT (P < 0.001), KEP score (P = 0.015) and all meibomian gland parameters (all P < 0.001) between two groups. When the NTG group was divided into compliant and non-compliant groups based on the scores of MMAS-8, 30 (75%) patients were classified into the compliant group. Multiple logistic regression analysis revealed that the lid margin score (OR, 0.256; 95% CI, 0.072–0.908, P = 0.035), meibum score (OR, 0.144; 95% CI, 0.023–0.915, P = 0.04), and meibo score (OR, 0.344; 95% CI, 0.140–0.845, P = 0.02) were significant factors associated with compliance in patients with NTG. The meibomian gland parameters showed a negative correlation with medication compliance (all P < 0.005). CONCLUSIONS: Malfunction of the meibomian glands can be an important clinical finding associated with compliance of PGA monotherapy in patients with NTG. |
format | Online Article Text |
id | pubmed-5791996 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-57919962018-02-09 Association between meibomian gland dysfunction and compliance of topical prostaglandin analogs in patients with normal tension glaucoma Lee, Tae Hee Sung, Mi Sun Heo, Hwan Park, Sang Woo PLoS One Research Article PURPOSE: The aim of this study was to investigate the association between tear film and meibomian gland parameters in patients with normal tension glaucoma (NTG), who underwent topical prostaglandin analog (PGA) monotherapy, and medication compliance. METHODS: Ocular surface disease index (OSDI), Schirmer’s test, tear film break-up time (TBUT), keratoepitheliopathy (KEP) score with fluorescein, and meibomian gland parameters were assessed in 45 eyes of 45 patients with NTG (NTG group), who received topical PGA monotherapy for more than 1 year. The results were compared to those of 40 eyes of 40 normal subjects (control group). Medication compliance was assessed by an 8-item Morisky Medication Adherence Scale (MMAS-8). Multiple logistic regression analysis was used to identify the factors associated with medication compliance. RESULTS: There was a significant difference in OSDI (P = 0.043), Schirmer’s test (P < 0.001), TBUT (P < 0.001), KEP score (P = 0.015) and all meibomian gland parameters (all P < 0.001) between two groups. When the NTG group was divided into compliant and non-compliant groups based on the scores of MMAS-8, 30 (75%) patients were classified into the compliant group. Multiple logistic regression analysis revealed that the lid margin score (OR, 0.256; 95% CI, 0.072–0.908, P = 0.035), meibum score (OR, 0.144; 95% CI, 0.023–0.915, P = 0.04), and meibo score (OR, 0.344; 95% CI, 0.140–0.845, P = 0.02) were significant factors associated with compliance in patients with NTG. The meibomian gland parameters showed a negative correlation with medication compliance (all P < 0.005). CONCLUSIONS: Malfunction of the meibomian glands can be an important clinical finding associated with compliance of PGA monotherapy in patients with NTG. Public Library of Science 2018-01-31 /pmc/articles/PMC5791996/ /pubmed/29385185 http://dx.doi.org/10.1371/journal.pone.0191398 Text en © 2018 Lee et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Lee, Tae Hee Sung, Mi Sun Heo, Hwan Park, Sang Woo Association between meibomian gland dysfunction and compliance of topical prostaglandin analogs in patients with normal tension glaucoma |
title | Association between meibomian gland dysfunction and compliance of topical prostaglandin analogs in patients with normal tension glaucoma |
title_full | Association between meibomian gland dysfunction and compliance of topical prostaglandin analogs in patients with normal tension glaucoma |
title_fullStr | Association between meibomian gland dysfunction and compliance of topical prostaglandin analogs in patients with normal tension glaucoma |
title_full_unstemmed | Association between meibomian gland dysfunction and compliance of topical prostaglandin analogs in patients with normal tension glaucoma |
title_short | Association between meibomian gland dysfunction and compliance of topical prostaglandin analogs in patients with normal tension glaucoma |
title_sort | association between meibomian gland dysfunction and compliance of topical prostaglandin analogs in patients with normal tension glaucoma |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791996/ https://www.ncbi.nlm.nih.gov/pubmed/29385185 http://dx.doi.org/10.1371/journal.pone.0191398 |
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