Simvastatin and metformin inhibit cell growth in hepatitis C virus infected cells via mTOR increasing PTEN and autophagy

Hepatitis C virus (HCV) infection has been related to increased risk of development of hepatocellular carcinoma (HCC) while metformin (M) and statins treatment seemed to protect against HCC development. In this work, we aim to identify the mechanisms by which metformin and simvastatin (S) could prot...

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Detalles Bibliográficos
Autores principales: del Campo, José A., García-Valdecasas, Marta, Gil-Gómez, Antonio, Rojas, Ángela, Gallego, Paloma, Ampuero, Javier, Gallego-Durán, Rocío, Pastor, Helena, Grande, Lourdes, Padillo, Francisco J., Muntané, Jordi, Romero-Gómez, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791999/
https://www.ncbi.nlm.nih.gov/pubmed/29385181
http://dx.doi.org/10.1371/journal.pone.0191805

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