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A high carbohydrate, but not fat or protein meal attenuates postprandial ghrelin, PYY and GLP-1 responses in Chinese men
It is known that the macronutrient content of a meal has different impacts on the postprandial satiety and appetite hormonal responses. Whether obesity interacts with such nutrient-dependent responses is not well characterized. We examined the postprandial appetite and satiety hormonal responses aft...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792004/ https://www.ncbi.nlm.nih.gov/pubmed/29385178 http://dx.doi.org/10.1371/journal.pone.0191609 |
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author | Parvaresh Rizi, Ehsan Loh, Tze Ping Baig, Sonia Chhay, Vanna Huang, Shiqi Caleb Quek, Jonathan Tai, E. Shyong Toh, Sue-Anne Khoo, Chin Meng |
author_facet | Parvaresh Rizi, Ehsan Loh, Tze Ping Baig, Sonia Chhay, Vanna Huang, Shiqi Caleb Quek, Jonathan Tai, E. Shyong Toh, Sue-Anne Khoo, Chin Meng |
author_sort | Parvaresh Rizi, Ehsan |
collection | PubMed |
description | It is known that the macronutrient content of a meal has different impacts on the postprandial satiety and appetite hormonal responses. Whether obesity interacts with such nutrient-dependent responses is not well characterized. We examined the postprandial appetite and satiety hormonal responses after a high-protein (HP), high-carbohydrate (HC), or high-fat (HF) mixed meal. This was a randomized cross-over study of 9 lean insulin-sensitive (mean±SEM HOMA-IR 0.83±0.10) and 9 obese insulin-resistant (HOMA-IR 4.34±0.41) young (age 21–40 years), normoglycaemic Chinese men. We measured fasting and postprandial plasma concentration of glucose, insulin, active glucagon-like peptide-1 (GLP-1), total peptide-YY (PYY), and acyl-ghrelin in response to HP, HF, or HC meals. Overall postprandial plasma insulin response was more robust in the lean compared to obese subjects. The postprandial GLP-1 response after HF or HP meal was higher than HC meal in both lean and obese subjects. In obese subjects, HF meal induced higher response in postprandial PYY compared to HC meal. HP and HF meals also suppressed ghrelin greater compared to HC meal in the obese than lean subjects. In conclusion, a high-protein or high-fat meal induces a more favorable postprandial satiety and appetite hormonal response than a high-carbohydrate meal in obese insulin-resistant subjects. |
format | Online Article Text |
id | pubmed-5792004 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-57920042018-02-09 A high carbohydrate, but not fat or protein meal attenuates postprandial ghrelin, PYY and GLP-1 responses in Chinese men Parvaresh Rizi, Ehsan Loh, Tze Ping Baig, Sonia Chhay, Vanna Huang, Shiqi Caleb Quek, Jonathan Tai, E. Shyong Toh, Sue-Anne Khoo, Chin Meng PLoS One Research Article It is known that the macronutrient content of a meal has different impacts on the postprandial satiety and appetite hormonal responses. Whether obesity interacts with such nutrient-dependent responses is not well characterized. We examined the postprandial appetite and satiety hormonal responses after a high-protein (HP), high-carbohydrate (HC), or high-fat (HF) mixed meal. This was a randomized cross-over study of 9 lean insulin-sensitive (mean±SEM HOMA-IR 0.83±0.10) and 9 obese insulin-resistant (HOMA-IR 4.34±0.41) young (age 21–40 years), normoglycaemic Chinese men. We measured fasting and postprandial plasma concentration of glucose, insulin, active glucagon-like peptide-1 (GLP-1), total peptide-YY (PYY), and acyl-ghrelin in response to HP, HF, or HC meals. Overall postprandial plasma insulin response was more robust in the lean compared to obese subjects. The postprandial GLP-1 response after HF or HP meal was higher than HC meal in both lean and obese subjects. In obese subjects, HF meal induced higher response in postprandial PYY compared to HC meal. HP and HF meals also suppressed ghrelin greater compared to HC meal in the obese than lean subjects. In conclusion, a high-protein or high-fat meal induces a more favorable postprandial satiety and appetite hormonal response than a high-carbohydrate meal in obese insulin-resistant subjects. Public Library of Science 2018-01-31 /pmc/articles/PMC5792004/ /pubmed/29385178 http://dx.doi.org/10.1371/journal.pone.0191609 Text en © 2018 Parvaresh Rizi et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Parvaresh Rizi, Ehsan Loh, Tze Ping Baig, Sonia Chhay, Vanna Huang, Shiqi Caleb Quek, Jonathan Tai, E. Shyong Toh, Sue-Anne Khoo, Chin Meng A high carbohydrate, but not fat or protein meal attenuates postprandial ghrelin, PYY and GLP-1 responses in Chinese men |
title | A high carbohydrate, but not fat or protein meal attenuates postprandial ghrelin, PYY and GLP-1 responses in Chinese men |
title_full | A high carbohydrate, but not fat or protein meal attenuates postprandial ghrelin, PYY and GLP-1 responses in Chinese men |
title_fullStr | A high carbohydrate, but not fat or protein meal attenuates postprandial ghrelin, PYY and GLP-1 responses in Chinese men |
title_full_unstemmed | A high carbohydrate, but not fat or protein meal attenuates postprandial ghrelin, PYY and GLP-1 responses in Chinese men |
title_short | A high carbohydrate, but not fat or protein meal attenuates postprandial ghrelin, PYY and GLP-1 responses in Chinese men |
title_sort | high carbohydrate, but not fat or protein meal attenuates postprandial ghrelin, pyy and glp-1 responses in chinese men |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792004/ https://www.ncbi.nlm.nih.gov/pubmed/29385178 http://dx.doi.org/10.1371/journal.pone.0191609 |
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