ABCC6 plays a significant role in the transport of nilotinib and dasatinib, and contributes to TKI resistance in vitro, in both cell lines and primary patient mononuclear cells

ATP Binding Cassette family efflux proteins ABCB1 and ABCG2 have previously been demonstrated to interact with Tyrosine Kinase Inhibitors (TKIs); however, evidence for the interaction of other potentially relevant drug transporters with TKIs is lacking. Through Taqman transporter array technology we...

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Detalles Bibliográficos
Autores principales: Eadie, Laura N., Dang, Phuong, Goyne, Jarrad M., Hughes, Timothy P., White, Deborah L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792028/
https://www.ncbi.nlm.nih.gov/pubmed/29385210
http://dx.doi.org/10.1371/journal.pone.0192180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792028/
https://www.ncbi.nlm.nih.gov/pubmed/29385210
http://dx.doi.org/10.1371/journal.pone.0192180

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