Ratiometric sensing of BiP-client versus BiP levels by the unfolded protein response determines its signaling amplitude

Insufficient folding capacity of the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) to restore homeostasis. Yet, how the UPR achieves ER homeostatic readjustment is poorly investigated, as in most studies the ER stress that is elicited cannot be overcome. Here we show that...

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Detalles Bibliográficos
Autores principales: Bakunts, Anush, Orsi, Andrea, Vitale, Milena, Cattaneo, Angela, Lari, Federica, Tadè, Laura, Sitia, Roberto, Raimondi, Andrea, Bachi, Angela, van Anken, Eelco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792092/
https://www.ncbi.nlm.nih.gov/pubmed/29251598
http://dx.doi.org/10.7554/eLife.27518

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