Discrete roles and bifurcation of PTEN signaling and mTORC1-mediated anabolic metabolism underlie IL-7–driven B lymphopoiesis

Interleukin-7 (IL-7) drives early B lymphopoiesis, but the underlying molecular circuits remain poorly understood, especially how Stat5 (signal transducer and activator of transcription 5)–dependent and Stat5-independent pathways contribute to this process. Combining transcriptome and proteome analy...

Descripción completa

Detalles Bibliográficos
Autores principales: Zeng, Hu, Yu, Mei, Tan, Haiyan, Li, Yuxin, Su, Wei, Shi, Hao, Dhungana, Yogesh, Guy, Cliff, Neale, Geoffrey, Cloer, Caryn, Peng, Junmin, Wang, Demin, Chi, Hongbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792226/
https://www.ncbi.nlm.nih.gov/pubmed/29399633
http://dx.doi.org/10.1126/sciadv.aar5701

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792226/
https://www.ncbi.nlm.nih.gov/pubmed/29399633
http://dx.doi.org/10.1126/sciadv.aar5701

Ejemplares similares