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Functional Principles of Posterior Septal Inputs to the Medial Habenula
The medial habenula (MHb) is an epithalamic hub contributing to expression and extinction of aversive states by bridging forebrain areas and midbrain monoaminergic centers. Although contradictory information exists regarding their synaptic properties, the physiology of the excitatory inputs to the M...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792424/ https://www.ncbi.nlm.nih.gov/pubmed/29346767 http://dx.doi.org/10.1016/j.celrep.2017.12.064 |
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author | Otsu, Yo Lecca, Salvatore Pietrajtis, Katarzyna Rousseau, Charly Vincent Marcaggi, Païkan Dugué, Guillaume Pierre Mailhes-Hamon, Caroline Mameli, Manuel Diana, Marco Alberto |
author_facet | Otsu, Yo Lecca, Salvatore Pietrajtis, Katarzyna Rousseau, Charly Vincent Marcaggi, Païkan Dugué, Guillaume Pierre Mailhes-Hamon, Caroline Mameli, Manuel Diana, Marco Alberto |
author_sort | Otsu, Yo |
collection | PubMed |
description | The medial habenula (MHb) is an epithalamic hub contributing to expression and extinction of aversive states by bridging forebrain areas and midbrain monoaminergic centers. Although contradictory information exists regarding their synaptic properties, the physiology of the excitatory inputs to the MHb from the posterior septum remains elusive. Here, combining optogenetics-based mapping with ex vivo and in vivo physiology, we examine the synaptic properties of posterior septal afferents to the MHb and how they influence behavior. We demonstrate that MHb cells receive sparse inputs producing purely glutamatergic responses via calcium-permeable α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), heterotrimeric GluN2A-GluN2B-GluN1 N-methyl-D-aspartate (NMDA) receptors, and inhibitory group II metabotropic glutamate receptors. We describe the complex integration dynamics of these components by MHb cells. Finally, we combine ex vivo data with realistic afferent firing patterns recorded in vivo to demonstrate that efficient optogenetic septal stimulation in the MHb induces anxiolysis and promotes locomotion, contributing long-awaited evidence in favor of the importance of this septo-habenular pathway. |
format | Online Article Text |
id | pubmed-5792424 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Cell Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-57924242018-02-08 Functional Principles of Posterior Septal Inputs to the Medial Habenula Otsu, Yo Lecca, Salvatore Pietrajtis, Katarzyna Rousseau, Charly Vincent Marcaggi, Païkan Dugué, Guillaume Pierre Mailhes-Hamon, Caroline Mameli, Manuel Diana, Marco Alberto Cell Rep Article The medial habenula (MHb) is an epithalamic hub contributing to expression and extinction of aversive states by bridging forebrain areas and midbrain monoaminergic centers. Although contradictory information exists regarding their synaptic properties, the physiology of the excitatory inputs to the MHb from the posterior septum remains elusive. Here, combining optogenetics-based mapping with ex vivo and in vivo physiology, we examine the synaptic properties of posterior septal afferents to the MHb and how they influence behavior. We demonstrate that MHb cells receive sparse inputs producing purely glutamatergic responses via calcium-permeable α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), heterotrimeric GluN2A-GluN2B-GluN1 N-methyl-D-aspartate (NMDA) receptors, and inhibitory group II metabotropic glutamate receptors. We describe the complex integration dynamics of these components by MHb cells. Finally, we combine ex vivo data with realistic afferent firing patterns recorded in vivo to demonstrate that efficient optogenetic septal stimulation in the MHb induces anxiolysis and promotes locomotion, contributing long-awaited evidence in favor of the importance of this septo-habenular pathway. Cell Press 2018-01-29 /pmc/articles/PMC5792424/ /pubmed/29346767 http://dx.doi.org/10.1016/j.celrep.2017.12.064 Text en © 2017 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Otsu, Yo Lecca, Salvatore Pietrajtis, Katarzyna Rousseau, Charly Vincent Marcaggi, Païkan Dugué, Guillaume Pierre Mailhes-Hamon, Caroline Mameli, Manuel Diana, Marco Alberto Functional Principles of Posterior Septal Inputs to the Medial Habenula |
title | Functional Principles of Posterior Septal Inputs to the Medial Habenula |
title_full | Functional Principles of Posterior Septal Inputs to the Medial Habenula |
title_fullStr | Functional Principles of Posterior Septal Inputs to the Medial Habenula |
title_full_unstemmed | Functional Principles of Posterior Septal Inputs to the Medial Habenula |
title_short | Functional Principles of Posterior Septal Inputs to the Medial Habenula |
title_sort | functional principles of posterior septal inputs to the medial habenula |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792424/ https://www.ncbi.nlm.nih.gov/pubmed/29346767 http://dx.doi.org/10.1016/j.celrep.2017.12.064 |
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