Derepression of the Iroquois Homeodomain Transcription Factor Gene IRX3 Confers Differentiation Block in Acute Leukemia

The Iroquois homeodomain transcription factor gene IRX3 is expressed in the developing nervous system, limb buds, and heart, and transcript levels specify obesity risk in humans. We now report a functional role for IRX3 in human acute leukemia. Although transcript levels are very low in normal human...

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Detalles Bibliográficos
Autores principales: Somerville, Tim D.D., Simeoni, Fabrizio, Chadwick, John A., Williams, Emma L., Spencer, Gary J., Boros, Katalin, Wirth, Christopher, Tholouli, Eleni, Byers, Richard J., Somervaille, Tim C.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792454/
https://www.ncbi.nlm.nih.gov/pubmed/29346763
http://dx.doi.org/10.1016/j.celrep.2017.12.063

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