Cargando…

Targeted Knockdown of Overexpressed VEGFA or VEGF164 in Müller cells maintains retinal function by triggering different signaling mechanisms

Oxygen-induced retinopathy (OIR) upregulates Müller cell vascular endothelial growth factor A (VEGFA) that causes intravitreal neovascularization similar to severe retinopathy of prematurity (ROP). Safety concerns exist with anti-VEGF treatment for ROP. We evaluated long-term knockdown of Müller cel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Becker, Silke, Wang, Haibo, Simmons, Aaron B., Suwanmanee, Thipparat, Stoddard, Gregory J., Kafri, Tal, Hartnett, M. Elizabeth
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792486/ https://www.ncbi.nlm.nih.gov/pubmed/29386650 http://dx.doi.org/10.1038/s41598-018-20278-4

Ejemplares similares

Gene therapy knockdown of VEGFR2 in retinal endothelial cells to treat retinopathy
por: Simmons, Aaron B., et al.
Publicado: (2018)

Correction to: Gene therapy knockdown of VEGFR2 in retinal endothelial cells to treat retinopathy
por: Simmons, Aaron B., et al.
Publicado: (2018)

Toward Personalized Gene Therapy: Characterizing the Host Genetic Control of Lentiviral-Vector-Mediated Hepatic Gene Delivery
por: Suwanmanee, Thipparat, et al.
Publicado: (2017)

Superior lentiviral vectors designed for BSL-0 environment abolish vector mobilization.
por: Hu, Peirong, et al.
Publicado: (2018)

Retinopathy of prematurity shows alterations in Vegfa(164) isoform expression
por: Mezu-Ndubuisi, Olachi J., et al.
Publicado: (2021)

Effect of subretinal injection on retinal structure and function in a rat oxygen-induced retinopathy model
por: Becker, Silke, et al.
Publicado: (2017)

Analysis of VEGFA Variants and Changes in VEGF Levels Underscores the Contribution of VEGF to Polycystic Ovary Syndrome
por: Almawi, Wassim Y, et al.
Publicado: (2016)

Anti-VEGF therapy prevents Müller intracellular edema by decreasing VEGF-A in diabetic retinopathy
por: Wang, Tianqin, et al.
Publicado: (2021)

VEGF(164)-mediated Inflammation Is Required for Pathological, but Not Physiological, Ischemia-induced Retinal Neovascularization
por: Ishida, Susumu, et al.
Publicado: (2003)

Effects of anti-VEGF agents on rat retinal Müller glial cells
por: Guo, Bin, et al.
Publicado: (2010)

VEGF-A isoform modulation in an preclinical TNBS model of ulcerative colitis: protective effects of a VEGF164(b) therapy
por: Cromer, Walter E, et al.
Publicado: (2013)

VEGFA Haplotype and VEGF-A and VEGF-R2 Protein Associations with Exudative Age-Related Macular Degeneration
por: Vilkeviciute, Alvita, et al.
Publicado: (2022)

Recombinant Goat VEGF164 Increases Hair Growth by Painting Process on the Skin of Shaved Mouse
por: Bao, Wenlei, et al.
Publicado: (2014)

VEGF-B Is an Autocrine Gliotrophic Factor for Müller Cells under Pathologic Conditions
por: Llorián-Salvador, María, et al.
Publicado: (2020)

VEGF Mediates Retinal Müller Cell Viability and Neuroprotection through BDNF in Diabetes
por: Le, Yun-Zheng, et al.
Publicado: (2021)

Non-proteolytic calpain-6 interacts with VEGFA and promotes angiogenesis by increasing VEGF secretion
por: Oh, Mijung, et al.
Publicado: (2019)

Müller Cell-Derived VEGF Is Essential for Diabetes-Induced Retinal Inflammation and Vascular Leakage
por: Wang, Juanjuan, et al.
Publicado: (2010)

VEGF-Independent Activation of Müller Cells by the Vitreous from Proliferative Diabetic Retinopathy Patients
por: Rezzola, Sara, et al.
Publicado: (2021)

Do anti-VEGFs used in the ophthalmic clinic cause Müller glial cell stress?
por: da Silva, Rafael André, et al.
Publicado: (2023)

Functional VEGFA knockdown with artificial 3′-tailed mirtrons defined by 5′ splice site and branch point
por: Kock, Kian Hong, et al.
Publicado: (2015)

Knockdown of TRAF3IP2 suppresses the expression of VEGFA and the proliferation of keratinocytes and vascular endothelial cells
por: Song, Yali, et al.
Publicado: (2019)

Knockdown of SERPINE1 reverses resistance of triple-negative breast cancer to paclitaxel via suppression of VEGFA
por: Zhang, Qian, et al.
Publicado: (2020)

Employing a Gain-of-Function Factor IX Variant R338L to Advance the Efficacy and Safety of Hemophilia B Human Gene Therapy: Preclinical Evaluation Supporting an Ongoing Adeno-Associated Virus Clinical Trial
por: Monahan, Paul E., et al.
Publicado: (2015)

Müller Glia maintain their regenerative potential despite degeneration in the aged zebrafish retina
por: Martins, Raquel R., et al.
Publicado: (2022)

Endogenous VEGF Is Required for Visual Function: Evidence for a Survival Role on Müller Cells and Photoreceptors
por: Saint-Geniez, Magali, et al.
Publicado: (2008)

Knockdown of Sly-miR164a Enhanced Plant Salt Tolerance and Improved Preharvest and Postharvest Fruit Nutrition of Tomato
por: Wan, Xue, et al.
Publicado: (2023)

Extrapolations to the Z = 164 region
por: Bengtsson, R
Publicado: (1970)

164th RB Meeting
por: CERN. Geneva. Research Board
Publicado: (2003)

Proangiogenic Interactions of Vascular Endothelial MMP14 With VEGF Receptor 1 in VEGFA-Mediated Corneal Angiogenesis
por: Han, Kyu-Yeon, et al.
Publicado: (2016)

TNF-α mediates choroidal neovascularization by upregulating VEGF expression in RPE through ROS-dependent β-catenin activation
por: Wang, Haibo, et al.
Publicado: (2016)

VEGF Upregulates EGFR Expression to Stimulate Chemotactic Behaviors in the rMC-1 Model of Müller Glia
por: Peña, Juan S., et al.
Publicado: (2020)

Knockdown of PPARδ Induces VEGFA-Mediated Angiogenesis via Interaction With ERO1A in Human Colorectal Cancer
por: Luo, Wenjun, et al.
Publicado: (2021)

Thy-1 Regulates VEGF-Mediated Choroidal Endothelial Cell Activation and Migration: Implications in Neovascular Age-Related Macular Degeneration
por: Wang, Haibo, et al.
Publicado: (2016)

Overexpressing NeuroD1 reprograms Müller cells into various types of retinal neurons
por: Xu, Di, et al.
Publicado: (2022)

Downregulation of miR-375 contributes to ERBB2-mediated VEGFA overexpression in esophageal cancer
por: Ren, Shuchang, et al.
Publicado: (2021)

IAU Symposium 164 : Stellar Populations
Publicado: (1994)

Health Tract, No. 164: Sickness Not Causeless
Publicado: (1863)

Health Tract, No. 164: Sickness Not Causeless
Publicado: (1865)

Long-term safety and stability of angiogenesis induced by balanced single-vector co-expression of PDGF-BB and VEGF(164) in skeletal muscle
por: Gianni-Barrera, Roberto, et al.
Publicado: (2016)

MicroRNA-16-5p overexpression suppresses proliferation and invasion as well as triggers apoptosis by targeting VEGFA expression in breast carcinoma
por: Qu, Yunhui, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_mvtvb2vml0o07r5puv4dnk4pgb