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Targeted Knockdown of Overexpressed VEGFA or VEGF164 in Müller cells maintains retinal function by triggering different signaling mechanisms

Oxygen-induced retinopathy (OIR) upregulates Müller cell vascular endothelial growth factor A (VEGFA) that causes intravitreal neovascularization similar to severe retinopathy of prematurity (ROP). Safety concerns exist with anti-VEGF treatment for ROP. We evaluated long-term knockdown of Müller cel...

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Detalles Bibliográficos
Autores principales:	Becker, Silke, Wang, Haibo, Simmons, Aaron B., Suwanmanee, Thipparat, Stoddard, Gregory J., Kafri, Tal, Hartnett, M. Elizabeth
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792486/ https://www.ncbi.nlm.nih.gov/pubmed/29386650 http://dx.doi.org/10.1038/s41598-018-20278-4

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