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IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells
X-linked lymphoproliferative syndrome type-2 (XLP-2) is a primary immunodeficiency disease attributed to XIAP mutation and is triggered by infection. Here, we show that mouse Xiap(−/−) regulatory T (Treg) cells and human XIAP-deficient Treg cells are defective in suppressive function. The Xiap(−/−)...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792625/ https://www.ncbi.nlm.nih.gov/pubmed/29386580 http://dx.doi.org/10.1038/s41467-018-02862-4 |