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Incidence and seasonality of respiratory syncytial virus hospitalisations in young children in Denmark, 2010 to 2015

For future decisions on respiratory syncytial virus (RSV)-vaccination strategies and implementation into national immunisation-programmes, we used national registry data (hospitalisation, microbiology and vital statistics) to determine the age-specific incidence and direct medical costs of annual RS...

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Autores principales: Jepsen, Martin T., Trebbien, Ramona, Emborg, Hanne Dorthe, Krause, Tyra G., Schønning, Kristian, Voldstedlund, Marianne, Nielsen, Jens, Fischer, Thea K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792699/
https://www.ncbi.nlm.nih.gov/pubmed/29386093
http://dx.doi.org/10.2807/1560-7917.ES.2018.23.3.17-00163
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author Jepsen, Martin T.
Trebbien, Ramona
Emborg, Hanne Dorthe
Krause, Tyra G.
Schønning, Kristian
Voldstedlund, Marianne
Nielsen, Jens
Fischer, Thea K.
author_facet Jepsen, Martin T.
Trebbien, Ramona
Emborg, Hanne Dorthe
Krause, Tyra G.
Schønning, Kristian
Voldstedlund, Marianne
Nielsen, Jens
Fischer, Thea K.
author_sort Jepsen, Martin T.
collection PubMed
description For future decisions on respiratory syncytial virus (RSV)-vaccination strategies and implementation into national immunisation-programmes, we used national registry data (hospitalisation, microbiology and vital statistics) to determine the age-specific incidence and direct medical costs of annual RSV-associated admissions in children < 5 years-old for the period of 2010–2015. We identified ca 2,500 RSV-associated hospitalisations annually amounting to total direct medical-costs of ca EUR 4.1 million per year. The incidence of RSV-associated hospitalisations peaked in infants 1–2 months of age followed by infants 2–3 months of age, and infants < 1 month of age, respectively. Infant boys were at higher risk of severe RSV infection as compared to infant girls: male-to-female ratio peaked with 1.4 at four months of age and gradually levelled out with increasing age to 1.0 at 4 years of age. Five RSV-associated deaths were identified. Our findings demonstrate that in a western country as Denmark, RSV constitutes a considerable burden on childhood health. Furthermore, the best approach to reduce the high incidence of RSV-associated hospitalisations in young infants < 3 months of age may be maternal vaccination due to general challenges in achieving sufficient and protective immune responses in young infants.
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spelling pubmed-57926992018-03-23 Incidence and seasonality of respiratory syncytial virus hospitalisations in young children in Denmark, 2010 to 2015 Jepsen, Martin T. Trebbien, Ramona Emborg, Hanne Dorthe Krause, Tyra G. Schønning, Kristian Voldstedlund, Marianne Nielsen, Jens Fischer, Thea K. Euro Surveill Surveillance and Outbreak Report For future decisions on respiratory syncytial virus (RSV)-vaccination strategies and implementation into national immunisation-programmes, we used national registry data (hospitalisation, microbiology and vital statistics) to determine the age-specific incidence and direct medical costs of annual RSV-associated admissions in children < 5 years-old for the period of 2010–2015. We identified ca 2,500 RSV-associated hospitalisations annually amounting to total direct medical-costs of ca EUR 4.1 million per year. The incidence of RSV-associated hospitalisations peaked in infants 1–2 months of age followed by infants 2–3 months of age, and infants < 1 month of age, respectively. Infant boys were at higher risk of severe RSV infection as compared to infant girls: male-to-female ratio peaked with 1.4 at four months of age and gradually levelled out with increasing age to 1.0 at 4 years of age. Five RSV-associated deaths were identified. Our findings demonstrate that in a western country as Denmark, RSV constitutes a considerable burden on childhood health. Furthermore, the best approach to reduce the high incidence of RSV-associated hospitalisations in young infants < 3 months of age may be maternal vaccination due to general challenges in achieving sufficient and protective immune responses in young infants. European Centre for Disease Prevention and Control (ECDC) 2018-01-18 /pmc/articles/PMC5792699/ /pubmed/29386093 http://dx.doi.org/10.2807/1560-7917.ES.2018.23.3.17-00163 Text en This article is copyright of The Authors, 2018. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Surveillance and Outbreak Report
Jepsen, Martin T.
Trebbien, Ramona
Emborg, Hanne Dorthe
Krause, Tyra G.
Schønning, Kristian
Voldstedlund, Marianne
Nielsen, Jens
Fischer, Thea K.
Incidence and seasonality of respiratory syncytial virus hospitalisations in young children in Denmark, 2010 to 2015
title Incidence and seasonality of respiratory syncytial virus hospitalisations in young children in Denmark, 2010 to 2015
title_full Incidence and seasonality of respiratory syncytial virus hospitalisations in young children in Denmark, 2010 to 2015
title_fullStr Incidence and seasonality of respiratory syncytial virus hospitalisations in young children in Denmark, 2010 to 2015
title_full_unstemmed Incidence and seasonality of respiratory syncytial virus hospitalisations in young children in Denmark, 2010 to 2015
title_short Incidence and seasonality of respiratory syncytial virus hospitalisations in young children in Denmark, 2010 to 2015
title_sort incidence and seasonality of respiratory syncytial virus hospitalisations in young children in denmark, 2010 to 2015
topic Surveillance and Outbreak Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792699/
https://www.ncbi.nlm.nih.gov/pubmed/29386093
http://dx.doi.org/10.2807/1560-7917.ES.2018.23.3.17-00163
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