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A Structural View of Xenophagy, a Battle between Host and Microbes
The cytoplasm in mammalian cells is a battlefield between the host and invading microbes. Both the living organisms have evolved unique strategies for their survival. The host utilizes a specialized autophagy system, xenophagy, for the clearance of invading pathogens, whereas bacteria secrete protei...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society for Molecular and Cellular Biology
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792709/ https://www.ncbi.nlm.nih.gov/pubmed/29370690 http://dx.doi.org/10.14348/molcells.2018.2274 |
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author | Kwon, Do Hoon Song, Hyun Kyu |
author_facet | Kwon, Do Hoon Song, Hyun Kyu |
author_sort | Kwon, Do Hoon |
collection | PubMed |
description | The cytoplasm in mammalian cells is a battlefield between the host and invading microbes. Both the living organisms have evolved unique strategies for their survival. The host utilizes a specialized autophagy system, xenophagy, for the clearance of invading pathogens, whereas bacteria secrete proteins to defend and escape from the host xenophagy. Several molecules have been identified and their structural investigation has enabled the comprehension of these mechanisms at the molecular level. In this review, we focus on one example of host autophagy and the other of bacterial defense: the autophagy receptor, NDP52, in conjunction with the sugar receptor, galectin-8, plays a critical role in targeting the autophagy machinery against Salmonella; and the cysteine protease, RavZ secreted by Legionella pneumophila cleaves the LC3-PE on the phagophore membrane. The structure-function relationships of these two examples and the directions of future research will be discussed. |
format | Online Article Text |
id | pubmed-5792709 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Korean Society for Molecular and Cellular Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-57927092018-02-14 A Structural View of Xenophagy, a Battle between Host and Microbes Kwon, Do Hoon Song, Hyun Kyu Mol Cells Minireview The cytoplasm in mammalian cells is a battlefield between the host and invading microbes. Both the living organisms have evolved unique strategies for their survival. The host utilizes a specialized autophagy system, xenophagy, for the clearance of invading pathogens, whereas bacteria secrete proteins to defend and escape from the host xenophagy. Several molecules have been identified and their structural investigation has enabled the comprehension of these mechanisms at the molecular level. In this review, we focus on one example of host autophagy and the other of bacterial defense: the autophagy receptor, NDP52, in conjunction with the sugar receptor, galectin-8, plays a critical role in targeting the autophagy machinery against Salmonella; and the cysteine protease, RavZ secreted by Legionella pneumophila cleaves the LC3-PE on the phagophore membrane. The structure-function relationships of these two examples and the directions of future research will be discussed. Korean Society for Molecular and Cellular Biology 2018-01-31 2018-01-23 /pmc/articles/PMC5792709/ /pubmed/29370690 http://dx.doi.org/10.14348/molcells.2018.2274 Text en © The Korean Society for Molecular and Cellular Biology. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/. |
spellingShingle | Minireview Kwon, Do Hoon Song, Hyun Kyu A Structural View of Xenophagy, a Battle between Host and Microbes |
title | A Structural View of Xenophagy, a Battle between Host and Microbes |
title_full | A Structural View of Xenophagy, a Battle between Host and Microbes |
title_fullStr | A Structural View of Xenophagy, a Battle between Host and Microbes |
title_full_unstemmed | A Structural View of Xenophagy, a Battle between Host and Microbes |
title_short | A Structural View of Xenophagy, a Battle between Host and Microbes |
title_sort | structural view of xenophagy, a battle between host and microbes |
topic | Minireview |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792709/ https://www.ncbi.nlm.nih.gov/pubmed/29370690 http://dx.doi.org/10.14348/molcells.2018.2274 |
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