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A Structural View of Xenophagy, a Battle between Host and Microbes

The cytoplasm in mammalian cells is a battlefield between the host and invading microbes. Both the living organisms have evolved unique strategies for their survival. The host utilizes a specialized autophagy system, xenophagy, for the clearance of invading pathogens, whereas bacteria secrete protei...

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Detalles Bibliográficos
Autores principales: Kwon, Do Hoon, Song, Hyun Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Molecular and Cellular Biology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792709/
https://www.ncbi.nlm.nih.gov/pubmed/29370690
http://dx.doi.org/10.14348/molcells.2018.2274
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author Kwon, Do Hoon
Song, Hyun Kyu
author_facet Kwon, Do Hoon
Song, Hyun Kyu
author_sort Kwon, Do Hoon
collection PubMed
description The cytoplasm in mammalian cells is a battlefield between the host and invading microbes. Both the living organisms have evolved unique strategies for their survival. The host utilizes a specialized autophagy system, xenophagy, for the clearance of invading pathogens, whereas bacteria secrete proteins to defend and escape from the host xenophagy. Several molecules have been identified and their structural investigation has enabled the comprehension of these mechanisms at the molecular level. In this review, we focus on one example of host autophagy and the other of bacterial defense: the autophagy receptor, NDP52, in conjunction with the sugar receptor, galectin-8, plays a critical role in targeting the autophagy machinery against Salmonella; and the cysteine protease, RavZ secreted by Legionella pneumophila cleaves the LC3-PE on the phagophore membrane. The structure-function relationships of these two examples and the directions of future research will be discussed.
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spelling pubmed-57927092018-02-14 A Structural View of Xenophagy, a Battle between Host and Microbes Kwon, Do Hoon Song, Hyun Kyu Mol Cells Minireview The cytoplasm in mammalian cells is a battlefield between the host and invading microbes. Both the living organisms have evolved unique strategies for their survival. The host utilizes a specialized autophagy system, xenophagy, for the clearance of invading pathogens, whereas bacteria secrete proteins to defend and escape from the host xenophagy. Several molecules have been identified and their structural investigation has enabled the comprehension of these mechanisms at the molecular level. In this review, we focus on one example of host autophagy and the other of bacterial defense: the autophagy receptor, NDP52, in conjunction with the sugar receptor, galectin-8, plays a critical role in targeting the autophagy machinery against Salmonella; and the cysteine protease, RavZ secreted by Legionella pneumophila cleaves the LC3-PE on the phagophore membrane. The structure-function relationships of these two examples and the directions of future research will be discussed. Korean Society for Molecular and Cellular Biology 2018-01-31 2018-01-23 /pmc/articles/PMC5792709/ /pubmed/29370690 http://dx.doi.org/10.14348/molcells.2018.2274 Text en © The Korean Society for Molecular and Cellular Biology. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/.
spellingShingle Minireview
Kwon, Do Hoon
Song, Hyun Kyu
A Structural View of Xenophagy, a Battle between Host and Microbes
title A Structural View of Xenophagy, a Battle between Host and Microbes
title_full A Structural View of Xenophagy, a Battle between Host and Microbes
title_fullStr A Structural View of Xenophagy, a Battle between Host and Microbes
title_full_unstemmed A Structural View of Xenophagy, a Battle between Host and Microbes
title_short A Structural View of Xenophagy, a Battle between Host and Microbes
title_sort structural view of xenophagy, a battle between host and microbes
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792709/
https://www.ncbi.nlm.nih.gov/pubmed/29370690
http://dx.doi.org/10.14348/molcells.2018.2274
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