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Biological Roles of Alternative Autophagy
Atg5 and Atg7 have long been considered as essential molecules for autophagy. However, we found that cells lacking these molecules still form autophagic vacuoles and perform autophagic protein degradation when subjected to certain stressors. During this unconventional autophagy pathway, autophagosom...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Society for Molecular and Cellular Biology
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792713/ https://www.ncbi.nlm.nih.gov/pubmed/29370693 http://dx.doi.org/10.14348/molcells.2018.2215 |
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author | Shimizu, Shigeomi |
author_facet | Shimizu, Shigeomi |
author_sort | Shimizu, Shigeomi |
collection | PubMed |
description | Atg5 and Atg7 have long been considered as essential molecules for autophagy. However, we found that cells lacking these molecules still form autophagic vacuoles and perform autophagic protein degradation when subjected to certain stressors. During this unconventional autophagy pathway, autophagosomes appeared to be generated in a Rab9-dependent manner by the fusion of vesicles derived from the trans-Golgi and late endosomes. Therefore, mammalian autophagy can occur via at least two different pathways; the Atg5/Atg7-dependent conventional pathway and an Atg5/Atg7-independent alternative pathway. |
format | Online Article Text |
id | pubmed-5792713 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Korean Society for Molecular and Cellular Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-57927132018-02-14 Biological Roles of Alternative Autophagy Shimizu, Shigeomi Mol Cells Minireview Atg5 and Atg7 have long been considered as essential molecules for autophagy. However, we found that cells lacking these molecules still form autophagic vacuoles and perform autophagic protein degradation when subjected to certain stressors. During this unconventional autophagy pathway, autophagosomes appeared to be generated in a Rab9-dependent manner by the fusion of vesicles derived from the trans-Golgi and late endosomes. Therefore, mammalian autophagy can occur via at least two different pathways; the Atg5/Atg7-dependent conventional pathway and an Atg5/Atg7-independent alternative pathway. Korean Society for Molecular and Cellular Biology 2018-01-31 2018-01-23 /pmc/articles/PMC5792713/ /pubmed/29370693 http://dx.doi.org/10.14348/molcells.2018.2215 Text en © The Korean Society for Molecular and Cellular Biology. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/. |
spellingShingle | Minireview Shimizu, Shigeomi Biological Roles of Alternative Autophagy |
title | Biological Roles of Alternative Autophagy |
title_full | Biological Roles of Alternative Autophagy |
title_fullStr | Biological Roles of Alternative Autophagy |
title_full_unstemmed | Biological Roles of Alternative Autophagy |
title_short | Biological Roles of Alternative Autophagy |
title_sort | biological roles of alternative autophagy |
topic | Minireview |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792713/ https://www.ncbi.nlm.nih.gov/pubmed/29370693 http://dx.doi.org/10.14348/molcells.2018.2215 |
work_keys_str_mv | AT shimizushigeomi biologicalrolesofalternativeautophagy |