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Deletion/loss of bone morphogenetic protein 7 changes tooth morphology and function in Mus musculus: implications for dental evolution in mammals

Quantifying regulatory gene effects on dental morphology and function has implications for the underlying mechanisms that generated dental diversity in mammals. We tested the hypothesis that regulatory gene expression changes lead to differences in molars using a neural crest knockout of bone morpho...

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Autores principales: Zurowski, Chelsey, Jamniczky, Heather, Graf, Daniel, Theodor, Jessica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society Publishing 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792877/
https://www.ncbi.nlm.nih.gov/pubmed/29410800
http://dx.doi.org/10.1098/rsos.170761
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author Zurowski, Chelsey
Jamniczky, Heather
Graf, Daniel
Theodor, Jessica
author_facet Zurowski, Chelsey
Jamniczky, Heather
Graf, Daniel
Theodor, Jessica
author_sort Zurowski, Chelsey
collection PubMed
description Quantifying regulatory gene effects on dental morphology and function has implications for the underlying mechanisms that generated dental diversity in mammals. We tested the hypothesis that regulatory gene expression changes lead to differences in molars using a neural crest knockout of bone morphogenetic protein 7 (BMP7) in Mus musculus. Three-dimensional geometric morphometric methods were used to quantify the shape of the molar toothrow. BMP7 mutants have extra cusps on the first upper and lower molars, and alterations in cusp orientation and morphology. Furthermore, significant shape differences between control and mutant were found for upper and lower toothrows. Mutant mice also exhibited differences in attrition facets, indicating functional changes that could lead to advantages in chewing new food resources and eventually niche diversification. The size ratio of the molars in the toothrow remained unchanged, implying that BMP7-induced changes in molar size ratio are a result of knocking out epithelial, rather than neural crest, expression of BMP7. Our results indicate that changes in BMP7 expression are sufficient to alter the morphology and function of the toothrow, suggesting that BMP7 or genes affecting its function could have played a role in structuring the dental diversity of extinct and extant mammals.
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spelling pubmed-57928772018-02-06 Deletion/loss of bone morphogenetic protein 7 changes tooth morphology and function in Mus musculus: implications for dental evolution in mammals Zurowski, Chelsey Jamniczky, Heather Graf, Daniel Theodor, Jessica R Soc Open Sci Biology (Whole Organism) Quantifying regulatory gene effects on dental morphology and function has implications for the underlying mechanisms that generated dental diversity in mammals. We tested the hypothesis that regulatory gene expression changes lead to differences in molars using a neural crest knockout of bone morphogenetic protein 7 (BMP7) in Mus musculus. Three-dimensional geometric morphometric methods were used to quantify the shape of the molar toothrow. BMP7 mutants have extra cusps on the first upper and lower molars, and alterations in cusp orientation and morphology. Furthermore, significant shape differences between control and mutant were found for upper and lower toothrows. Mutant mice also exhibited differences in attrition facets, indicating functional changes that could lead to advantages in chewing new food resources and eventually niche diversification. The size ratio of the molars in the toothrow remained unchanged, implying that BMP7-induced changes in molar size ratio are a result of knocking out epithelial, rather than neural crest, expression of BMP7. Our results indicate that changes in BMP7 expression are sufficient to alter the morphology and function of the toothrow, suggesting that BMP7 or genes affecting its function could have played a role in structuring the dental diversity of extinct and extant mammals. The Royal Society Publishing 2018-01-03 /pmc/articles/PMC5792877/ /pubmed/29410800 http://dx.doi.org/10.1098/rsos.170761 Text en © 2018 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Biology (Whole Organism)
Zurowski, Chelsey
Jamniczky, Heather
Graf, Daniel
Theodor, Jessica
Deletion/loss of bone morphogenetic protein 7 changes tooth morphology and function in Mus musculus: implications for dental evolution in mammals
title Deletion/loss of bone morphogenetic protein 7 changes tooth morphology and function in Mus musculus: implications for dental evolution in mammals
title_full Deletion/loss of bone morphogenetic protein 7 changes tooth morphology and function in Mus musculus: implications for dental evolution in mammals
title_fullStr Deletion/loss of bone morphogenetic protein 7 changes tooth morphology and function in Mus musculus: implications for dental evolution in mammals
title_full_unstemmed Deletion/loss of bone morphogenetic protein 7 changes tooth morphology and function in Mus musculus: implications for dental evolution in mammals
title_short Deletion/loss of bone morphogenetic protein 7 changes tooth morphology and function in Mus musculus: implications for dental evolution in mammals
title_sort deletion/loss of bone morphogenetic protein 7 changes tooth morphology and function in mus musculus: implications for dental evolution in mammals
topic Biology (Whole Organism)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792877/
https://www.ncbi.nlm.nih.gov/pubmed/29410800
http://dx.doi.org/10.1098/rsos.170761
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