Synthesis of gypsogenin derivatives with capabilities to arrest cell cycle and induce apoptosis in human cancer cells

Thirty-two gypsogenin derivatives were synthesized and screened for their cytotoxic activities. Their structures were established using IR, (1)H NMR, (13)C NMR, and LC-MS spectroscopic data. In MTT assays nearly all the compounds displayed good cytotoxicity in the low μM range for several human tumo...

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Detalles Bibliográficos
Autores principales: Zhang, Haochao, Mu, Yanling, Wang, Fengling, Song, Leling, Sun, Jie, Liu, Yongjun, Sun, Jingyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society Publishing 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792931/
https://www.ncbi.nlm.nih.gov/pubmed/29410854
http://dx.doi.org/10.1098/rsos.171510

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792931/
https://www.ncbi.nlm.nih.gov/pubmed/29410854
http://dx.doi.org/10.1098/rsos.171510

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